Axial levodopa-induced dyskinesias and neuronal activity in the dorsal striatum

Stephanie L. Alberico, Young Cho Kim, Tomas Lence, Nandakumar S. Narayanan

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Levodopa-induced dyskinesias are abnormal involuntary movements that limit the effectiveness of treatments for Parkinson's disease. Although dyskinesias involve the striatum, it is unclear how striatal neurons are involved in dyskinetic movements. Here we record from striatal neurons in mice during levodopa-induced axial dyskinesias. We developed an automated 3-dimensional motion tracking system to capture the development of axial dyskinesias at ∼10 ms resolution, and correlated these movements with neuronal activity of striatal medium spiny neurons and fast-spiking interneurons. The average firing rate of medium spiny neurons increased as axial dyskinesias developed, and both medium spiny neurons and fast-spiking interneurons were modulated around axial dyskinesias. We also found that delta field potential power increased in the striatum with dyskinesia, and that this increased delta power coupled with striatal neurons. Our findings provide insight into how striatal networks change as levodopa-induced dyskinesias develop, and suggest that increased medium spiny neuron firing, increased delta field potential power, and abnormal delta-coupling may be neurophysiological signatures of dyskinesias. These data could be helpful in understanding the role of the striatum in the pathogenesis of dyskinesias in Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)240-249
Number of pages10
StatePublished - Feb 20 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 IBRO


  • fast-spiking interneurons
  • levodopa-induced dyskinesia
  • medium spiny neurons
  • Parkinson's disease
  • tracking


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