A/W bioactive glass particles in HEPES solutions

Kai Zhang, David C. Bell, Lorraine F. Francis

Research output: Contribution to journalArticlepeer-review


A/W bioactive glass (BG) particles (600-1000 microns) were soaked in 0.1 M 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) solutions (0.01 g BG per 1 mL solution) at three pH ranges (acidic: 4.45-6.31, neutral: 7.45-7.64 and basic: 10.31-10.42). Crystalline calcium phosphates developed on BG surfaces after soaking in either acidic or neutral solutions. Electron diffraction (ED) results showed that whitlockite and octa-calcium phosphate (OCP) were the newly developed materials on BG in the acidic HEPES solution after soaking for 7 d and 14 d, respectively. Whitlockite also developed on the BG particles in the neutral solution of 0.5Na-HEPES after soaking for 14 d. No crystalline materials developed on BG surfaces after soaking in the basic Na-HEPES solution up to 14 d. The results of this study demonstrated that.the pH of a soaking solution strongly affect both the ions release of the A/W BG particles, and the development of crystalline calcium phosphates on BG particles.

Original languageEnglish (US)
Pages (from-to)501-504
Number of pages4
JournalKey Engineering Materials
StatePublished - Jan 1 2005


  • Bioactive glass
  • Calcium phosphates
  • Mineralization
  • pH


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