Avian sarcoma virus envelope glycoprotein (gp85) specifically binds chick embryo fibroblasts

C. F. Moldow, F. H. Reynolds, John R Lake, K. Lundberg, J. R. Stephensonv

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Highly purified Prague (Pr) strain Rous sarcoma virus (RSV) subgroup C envelope glycoprotein (gp85) is shown to bind cellular receptor sites present on C/E, and to a much lesser extent C/C, chicken embryo fibroblasts. The specificity of this binding activity is indicated by the fact that neither C/E nor C/C chicken embryo fibroblasts exhibit detectable binding of Rauscher murine leukemia virus envelope glycoprotein (gp70). Moreover, of the avian viruses tested, only those with subgroup C host range inhibit binding of 125I-labeled PrRSV-C gp85 by C/E chicken embryo fibroblasts. These findings provide a potential approach for quantitation and characterization of avian type C viral cellular receptor sites.

Original languageEnglish (US)
Pages (from-to)448-453
Number of pages6
Issue number2
StatePublished - Sep 1979

Bibliographical note

Funding Information:
The authorst hank L. Crittenden of the East Lansing Regional Poultry Center for the gift of line 15b embryos. This work was supportedu nder Public Health Service Grant CA-13722a nd Contract NOI-CO-75336, National Cancer Institute, NIH, Bethesda, Maryland 20014.

Copyright 2014 Elsevier B.V., All rights reserved.


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