Auxological evaluation and determinants of growth failure at the time of adoption in Eastern European adoptees

Bradley S. Miller, Maria G. Kroupina, Sandra L. Iverson, Patrick Mason, Christine Narad, John H. Himes, Dana E. Johnson, Anna Petryk

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Aim: To identify factors contributing to growth failure in international adoptees (IAs) from Eastern Europe. Study design: 138 IAs from Eastern Europe, 6-59 months old, were evaluated within 3 weeks of US arrival. Complete history, anthropometry, and serum for growth factors were obtained. Facial features were examined for risk of prenatal alcohol exposure. Results: Upon arrival, mean height (-1.23 ± 1.07), weight (-1.43 ± 1.29), and occipitofrontal circumference (OFC) (-0.63±1.10) SDS in las were significantly less than population means for US children. In a multiple regression model, age, low birth weight (LBW), insulin-like growth factor binding protein-3, and high risk for fetal alcohol syndrome were independent predictors of height SDS. LBW also independently predicted lower weight SDS and smaller OFC SDS. Conclusions: We recommend that IAs undergo screening upon US arrival to identify risk factors for poor growth, particularly evidence of LBW and fetal alcohol exposure. Catch-up growth should be monitored in all children following adoption.

Original languageEnglish (US)
Pages (from-to)31-39
Number of pages9
JournalJournal of Pediatric Endocrinology and Metabolism
Issue number1
StatePublished - Jan 2009


  • Adoption
  • Cortisol
  • Eastern Europe
  • Growth
  • Insulin-like growth factor


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