Autonomous immunity in mucosal epithelial cells: fortifying the barrier against infection

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations

Abstract

Mucosal epithelial cells express an autonomous innate immune response that controls the overgrowth of invaded bacteria, mitigates the harmful effects of the bacteria carried within, and does not rely on other external arms of the immune response. Epithelial cell autonomous innate immunity “respects” the social biology of invading bacteria to achieve symbiosis, and is the primary protective mechanism against pathogens.

Original languageEnglish (US)
Pages (from-to)387-398
Number of pages12
JournalMicrobes and Infection
Volume18
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • Antimicrobial proteins
  • Cell signaling
  • Infection
  • Innate immunity
  • Mucosal epithelium

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