TY - GEN
T1 - Automation of the detection of lung cancer cells in minimal samples of bronchioalveolar lavage
AU - Ortiz-De-Solorzano, Carlos
AU - Pengo, Thomas
AU - Galarraga, Miguel
AU - Muñoz-Barrutia, Arrate
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - We present the hardware and software specification of a quantitative, multidimensional and multispectral microscopy system designed for the detection of lung cancer using minimal samples of bronchoalveolar lavage (BAL). BAL samples were stained using FICTION: Fluorescence Immunophenotyping and Interphase Cytogenetics as a Tool for the Investigation of Neoplasms. Our system allows preliminary immunophenotypic detection of rare cancerous candidate cells, followed by accurate three-dimensional analysis of genomic integrity, to confirm or refute the initial assessment. Our results show that our automated analysis can accurately assist a human expert in the diagnostic evaluation of BAL samples.
AB - We present the hardware and software specification of a quantitative, multidimensional and multispectral microscopy system designed for the detection of lung cancer using minimal samples of bronchoalveolar lavage (BAL). BAL samples were stained using FICTION: Fluorescence Immunophenotyping and Interphase Cytogenetics as a Tool for the Investigation of Neoplasms. Our system allows preliminary immunophenotypic detection of rare cancerous candidate cells, followed by accurate three-dimensional analysis of genomic integrity, to confirm or refute the initial assessment. Our results show that our automated analysis can accurately assist a human expert in the diagnostic evaluation of BAL samples.
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U2 - 10.1109/ISBI.2008.4540995
DO - 10.1109/ISBI.2008.4540995
M3 - Conference contribution
AN - SCOPUS:51049123402
SN - 9781424420032
T3 - 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI
SP - 312
EP - 315
BT - 2008 5th IEEE International Symposium on Biomedical Imaging
T2 - 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI
Y2 - 14 May 2008 through 17 May 2008
ER -
