TY - JOUR
T1 - Autologous platelet-rich plasma
T2 - Evidence for clinical use
AU - Cohn, Claudia S.
AU - Lockhart, Evelyn
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Purpose of review Autologous platelet-rich plasma (aPRP) is growing in popularity as a therapy to augment wound healing, speed the recovery from muscle and joint injuries, and enhance recovery after surgical repair. High-profile athletes treated with aPRP have increased the demand from the general population. Yet, evidence to support the use of aPRP in most clinical settings is weak, because of poorly controlled clinical trials. Recent findings Preparations of aPRP vary by platelet count, leukocyte content, and degree of platelet activation. Nonetheless, these heterogeneous preparations are used in trials to assess the efficacy of aPRP treatment. Summary Despite weak evidence, the use of aPRP continues to grow. High-quality randomized controlled trials are needed to validate or repudiate the potential efficacy of aPRP. Standards for aPRP preparation and quality should be created.
AB - Purpose of review Autologous platelet-rich plasma (aPRP) is growing in popularity as a therapy to augment wound healing, speed the recovery from muscle and joint injuries, and enhance recovery after surgical repair. High-profile athletes treated with aPRP have increased the demand from the general population. Yet, evidence to support the use of aPRP in most clinical settings is weak, because of poorly controlled clinical trials. Recent findings Preparations of aPRP vary by platelet count, leukocyte content, and degree of platelet activation. Nonetheless, these heterogeneous preparations are used in trials to assess the efficacy of aPRP treatment. Summary Despite weak evidence, the use of aPRP continues to grow. High-quality randomized controlled trials are needed to validate or repudiate the potential efficacy of aPRP. Standards for aPRP preparation and quality should be created.
KW - Autologous platelet-rich plasma
KW - Cytokines
KW - Growth factors
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U2 - 10.1097/MOH.0000000000000183
DO - 10.1097/MOH.0000000000000183
M3 - Review article
C2 - 26390166
AN - SCOPUS:84944057183
VL - 22
SP - 527
EP - 532
JO - Current Opinion in Hematology
JF - Current Opinion in Hematology
SN - 1065-6251
IS - 6
ER -