Autologous islet transplantation: Challenges and lessons

Ty B. Dunn, Joshua J. Wilhelm, Melena D. Bellin, Timothy L. Pruett

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Purpose of review: Human islet isolation and autotransplantation [autologous islet transplant (AUTX)] is performed to prevent or ameliorate brittle diabetes after total pancreatectomy performed for benign disease. The success or failure of the transplant can be associated with a profound impact on the individual's quality of life and even survival. AUTX offers unique insights into the effects of pancreas quality, islet number, isolation technique and alternate site engraftment on transplant efficacy. Herein, we review islet isolation with a focus on potential pathways to further optimize the endocrine outcome of AUTX, and compare and contrast differences in islet processing for AUTX and allotransplantation (allogeneic islet transplant). Recent findings: New knowledge of human islet biology and issues surrounding the engraftment process offer opportunities for innovative approaches toward optimizing islet cell transplantation. Summary: Improving the rate and durability of insulin independence in the often-times marginal dose model of AUTX may provide new insight toward improving the efficiency and durability of single donor islet (allogeneic islet transplant).

Original languageEnglish (US)
Pages (from-to)364-371
Number of pages8
JournalCurrent Opinion in Organ Transplantation
Volume22
Issue number4
DOIs
StatePublished - Aug 1 2017

Fingerprint

Islets of Langerhans Transplantation
Autologous Transplantation
Transplants
Pancreatectomy
Cell Transplantation
Autografts
Islets of Langerhans
Pancreas
Quality of Life
Insulin
Survival

Keywords

  • engraftment
  • human islet transplantation
  • vascularization
  • viability

PubMed: MeSH publication types

  • Journal Article
  • Review

Cite this

Autologous islet transplantation : Challenges and lessons. / Dunn, Ty B.; Wilhelm, Joshua J.; Bellin, Melena D.; Pruett, Timothy L.

In: Current Opinion in Organ Transplantation, Vol. 22, No. 4, 01.08.2017, p. 364-371.

Research output: Contribution to journalReview article

@article{a7f5c1ebc1614ec196ffb61ae5bd7cfa,
title = "Autologous islet transplantation: Challenges and lessons",
abstract = "Purpose of review: Human islet isolation and autotransplantation [autologous islet transplant (AUTX)] is performed to prevent or ameliorate brittle diabetes after total pancreatectomy performed for benign disease. The success or failure of the transplant can be associated with a profound impact on the individual's quality of life and even survival. AUTX offers unique insights into the effects of pancreas quality, islet number, isolation technique and alternate site engraftment on transplant efficacy. Herein, we review islet isolation with a focus on potential pathways to further optimize the endocrine outcome of AUTX, and compare and contrast differences in islet processing for AUTX and allotransplantation (allogeneic islet transplant). Recent findings: New knowledge of human islet biology and issues surrounding the engraftment process offer opportunities for innovative approaches toward optimizing islet cell transplantation. Summary: Improving the rate and durability of insulin independence in the often-times marginal dose model of AUTX may provide new insight toward improving the efficiency and durability of single donor islet (allogeneic islet transplant).",
keywords = "engraftment, human islet transplantation, vascularization, viability",
author = "Dunn, {Ty B.} and Wilhelm, {Joshua J.} and Bellin, {Melena D.} and Pruett, {Timothy L.}",
year = "2017",
month = "8",
day = "1",
doi = "10.1097/MOT.0000000000000438",
language = "English (US)",
volume = "22",
pages = "364--371",
journal = "Current Opinion in Organ Transplantation",
issn = "1087-2418",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Autologous islet transplantation

T2 - Challenges and lessons

AU - Dunn, Ty B.

AU - Wilhelm, Joshua J.

AU - Bellin, Melena D.

AU - Pruett, Timothy L.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Purpose of review: Human islet isolation and autotransplantation [autologous islet transplant (AUTX)] is performed to prevent or ameliorate brittle diabetes after total pancreatectomy performed for benign disease. The success or failure of the transplant can be associated with a profound impact on the individual's quality of life and even survival. AUTX offers unique insights into the effects of pancreas quality, islet number, isolation technique and alternate site engraftment on transplant efficacy. Herein, we review islet isolation with a focus on potential pathways to further optimize the endocrine outcome of AUTX, and compare and contrast differences in islet processing for AUTX and allotransplantation (allogeneic islet transplant). Recent findings: New knowledge of human islet biology and issues surrounding the engraftment process offer opportunities for innovative approaches toward optimizing islet cell transplantation. Summary: Improving the rate and durability of insulin independence in the often-times marginal dose model of AUTX may provide new insight toward improving the efficiency and durability of single donor islet (allogeneic islet transplant).

AB - Purpose of review: Human islet isolation and autotransplantation [autologous islet transplant (AUTX)] is performed to prevent or ameliorate brittle diabetes after total pancreatectomy performed for benign disease. The success or failure of the transplant can be associated with a profound impact on the individual's quality of life and even survival. AUTX offers unique insights into the effects of pancreas quality, islet number, isolation technique and alternate site engraftment on transplant efficacy. Herein, we review islet isolation with a focus on potential pathways to further optimize the endocrine outcome of AUTX, and compare and contrast differences in islet processing for AUTX and allotransplantation (allogeneic islet transplant). Recent findings: New knowledge of human islet biology and issues surrounding the engraftment process offer opportunities for innovative approaches toward optimizing islet cell transplantation. Summary: Improving the rate and durability of insulin independence in the often-times marginal dose model of AUTX may provide new insight toward improving the efficiency and durability of single donor islet (allogeneic islet transplant).

KW - engraftment

KW - human islet transplantation

KW - vascularization

KW - viability

UR - http://www.scopus.com/inward/record.url?scp=85020127921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020127921&partnerID=8YFLogxK

U2 - 10.1097/MOT.0000000000000438

DO - 10.1097/MOT.0000000000000438

M3 - Review article

C2 - 28562418

AN - SCOPUS:85020127921

VL - 22

SP - 364

EP - 371

JO - Current Opinion in Organ Transplantation

JF - Current Opinion in Organ Transplantation

SN - 1087-2418

IS - 4

ER -