Autoimmunity: When self-tolerance breaks down

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The spontaneous development of destructive polyarthritis in mice transgenlc for an autoreactive T-cell receptor supports the notion that a failure of T-cell selftolerance can lead to similar diseases in humans, and sheds new light on the role of peripheral tolerance in the avoidance of such pathological immune responses.

Original languageEnglish (US)
Pages (from-to)R255-R257
JournalCurrent Biology
Issue number4
StatePublished - Apr 1997


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