Autoimmunity: When self-tolerance breaks down

Daniel L. Mueller; Marc K. Jenkins

doi:10.1016/s0960-9822(06)00115-1

Autoimmunity: When self-tolerance breaks down

Daniel L. Mueller, Marc K. Jenkins

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

The spontaneous development of destructive polyarthritis in mice transgenlc for an autoreactive T-cell receptor supports the notion that a failure of T-cell selftolerance can lead to similar diseases in humans, and sheds new light on the role of peripheral tolerance in the avoidance of such pathological immune responses.

Original language	English (US)
Pages (from-to)	R255-R257
Journal	Current Biology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1016/s0960-9822(06)00115-1
State	Published - Apr 1997

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title = "Autoimmunity: When self-tolerance breaks down",

abstract = "The spontaneous development of destructive polyarthritis in mice transgenlc for an autoreactive T-cell receptor supports the notion that a failure of T-cell selftolerance can lead to similar diseases in humans, and sheds new light on the role of peripheral tolerance in the avoidance of such pathological immune responses.",

author = "Mueller, {Daniel L.} and Jenkins, {Marc K.}",

year = "1997",

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AU - Mueller, Daniel L.

AU - Jenkins, Marc K.

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N2 - The spontaneous development of destructive polyarthritis in mice transgenlc for an autoreactive T-cell receptor supports the notion that a failure of T-cell selftolerance can lead to similar diseases in humans, and sheds new light on the role of peripheral tolerance in the avoidance of such pathological immune responses.

AB - The spontaneous development of destructive polyarthritis in mice transgenlc for an autoreactive T-cell receptor supports the notion that a failure of T-cell selftolerance can lead to similar diseases in humans, and sheds new light on the role of peripheral tolerance in the avoidance of such pathological immune responses.

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U2 - 10.1016/s0960-9822(06)00115-1

DO - 10.1016/s0960-9822(06)00115-1

M3 - Review article

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VL - 7

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JO - Current Biology

JF - Current Biology

SN - 0960-9822

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Autoimmunity: When self-tolerance breaks down

Abstract

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