Abstract
The spontaneous development of destructive polyarthritis in mice transgenlc for an autoreactive T-cell receptor supports the notion that a failure of T-cell selftolerance can lead to similar diseases in humans, and sheds new light on the role of peripheral tolerance in the avoidance of such pathological immune responses.
Original language | English (US) |
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Pages (from-to) | R255-R257 |
Journal | Current Biology |
Volume | 7 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1997 |