Autoimmune neutropenia of infancy and early childhood

Joseph P. Neglia, Jan Watterson, Mary Clay, William Kline, Naomi L.C. Luban, Clark M. Smith, John R. Priest

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Forty-one children were identified with autoimmune neutropenia of infancy and early childhood (absolute neutrophil count [ANC] less than 500/μ and demonstrable serum antineutrophil antibodies). There were 21 boys and 20 girls; the median age at diagnosis was 11 months (range 5-38 months). No life-threatening infections occurred. There was a gradual upward trend in ANC in all patients over many months, with 87% having an ANC >1000/μl by 24 months from diagnosis. Among various clinical and laboratory parameters analyzed statistically, only younger age at diagnosis was associated with earlier neutrophil recovery. There was no association between degree or duration of neutropenia and sex, race, antibody reactivity, or presence of serious illness at diagnosis.

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
JournalPediatric hematology and oncology
Issue number4
StatePublished - 1993

Bibliographical note

Funding Information:
Funded by Pine Tree Apple Tennis Classic Oncology Research Funds, Grant 5R0 1-H 1-2658-02 from the National Heart, Lung and Blood Institute and research funds from the American National Red Cross and the Children’s Cancer Research Fund of the University of Minnesota. J. P. Neglia is the recipient of the National Cancer Institute Clinical Investigator Award (CA 01240). The authors thank the numerous referring physicians and families from Minnesota, Wisconsin, and the Washington, D.C. area who provided us with information for this study. We also gratefully acknowledge the data collection efforts of Dr. Sylvia Gunawen.


  • Autoimmune
  • Childhood
  • Immune-mediated
  • Neutropenia


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