Autoantigens: the critical partner in initiating and propagating systemic autoimmunity.

W.D. Duan-Porter, L. Casciola-Rosen, A. Rosen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The increasing recognition that cancer is frequently associated with an autoantibody response, and observations that systemic autoimmunity is sometimes associated with the diagnosis of a variety of malignancies (many detected near the onset of autoimmune disease), strongly underscore a potential mechanistic connection between cancer immunity and systemic autoimmunity. Accumulating data suggest that autoantigens are critical partners in driving the autoimmune response. Furthermore, unique changes in antigen expression and conformation in the immunizing tumor and the target tissue may play a role in antigen selection and ongoing damage. This construct has important implications for diagnosis, monitoring, and treatment of autoimmunity and, potentially, cancer immunotherapy.
Original languageEnglish
Pages (from-to)127-136
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume1062
DOIs
StatePublished - 2005

Bibliographical note

Cited By :4

Export Date: 26 December 2018

Correspondence Address: Duan-Porter, W.D.

Keywords

  • autoantigen
  • autoimmune disease
  • chemistry
  • human
  • immunology
  • metabolism
  • pathology
  • physiology
  • review
  • Autoantigens
  • Autoimmune Diseases
  • Humans

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