Abstract
Autoantibody production occurs in juvenile idiopathic arthritis (JIA) and numerous other autoimmune diseases. In some conditions, the autoantibodies are clearly pathogenic, whereas in others the roles are less defined. Here we review various autoantibodies associated with JIA, with a particular focus on antinuclear antibodies and antibodies recognizing citrullinated self-antigens. We explore potential mechanisms that lead to the development of autoantibodies and the use of autoantibody testing in diagnosis and prognosis. Finally, we compare and contrast JIA-associated autoantibodies with those found in adults with rheumatoid arthritis (RA).
| Original language | English (US) |
|---|---|
| Article number | 3168 |
| Journal | Frontiers in immunology |
| Volume | 9 |
| Issue number | JAN |
| DOIs | |
| State | Published - 2019 |
Bibliographical note
Publisher Copyright:© 2019 Mahmud and Binstadt.
Keywords
- Anti-carbamylated protein antibodies
- Anti-citrullinated protein antibodies
- Antinuclear antibodies
- Autoantibodies
- Carbamylated self-antigens
- Citrullinated self-antigens
- Juvenile idiopathic arthritis
- Rheumatoid factor
- Autoimmunity
- Prognosis
- Autoantigens/immunology
- Humans
- Autoantibodies/immunology
- Protein Binding/immunology
- Immune Tolerance
- Rheumatoid Factor/immunology
- Antigen-Antibody Complex/blood
- Molecular Mimicry
- Arthritis, Juvenile/diagnosis
- Antibodies, Antinuclear/immunology
- Biomarkers
- Arthritis, Rheumatoid/diagnosis
PubMed: MeSH publication types
- Review
- Journal Article
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