Aurones: interesting natural and synthetic compounds with emerging biological potential.

Clemens Zwergel, François Gaascht, Sergio Valente, Marc Diederich, Denyse Bagrel, Gilbert Kirsch

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Aurones [2-benzylidenebenzofuran-3(2H)-ones] are either natural or synthetic compounds, belonging to the flavonoid family. They are isomeric to flavones and provide a bright yellow color to the plants in which they occur. Today, a literature survey indicates that the related flavonoids have been studied not only for their physiological properties and effects on Nature, but also for their therapeutic potential. Aurones are recently attracting the interest of an increasing number of research groups, and, since the last review, some interesting advances have been made in understanding the aurones. In this review, we report the recent advances made on the synthetic routes towards aurones. We also highlight their activity in different biological areas, as well as applied genetic plant modifications to produce these colored compounds. Their synthesis, structure-activity relationships and the importance of the substitution pattern will also be mentioned. Finally, some aspects regarding the possible development of aurones will be discussed briefly.
Original languageEnglish (US)
Pages (from-to)389-94
Number of pages6
JournalNatural Product Communications
Volume7
Issue number3
StatePublished - 2012

Keywords

  • Anti-Infective Agents
  • Anti-Infective Agents: analysis
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents: analysis
  • Antineoplastic Agents
  • Antineoplastic Agents: analysis
  • Benzofurans
  • Benzofurans: chemistry
  • Benzofurans: therapeutic use
  • Benzyl Compounds
  • Benzyl Compounds: chemistry
  • Benzyl Compounds: therapeutic use
  • Flowers
  • Flowers: chemistry
  • Fluorescent Dyes
  • Fluorescent Dyes: analysis
  • Skin Diseases
  • Skin Diseases: drug therapy
  • Structure-Activity Relationship

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