Atypical somatosensory-motor cortical response during vowel vocalization in spasmodic dysphonia

Sanaz Khosravani; Arash Mahnan; I. Ling Yeh; Peter J Watson; Yang Zhang; George Goding; Juergen Konczak

doi:10.1016/j.clinph.2019.03.003

Atypical somatosensory-motor cortical response during vowel vocalization in spasmodic dysphonia

Sanaz Khosravani, Arash Mahnan, I. Ling Yeh, Peter J Watson, Yang Zhang, George Goding, Juergen Konczak

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Objective: Spasmodic dysphonia (SD) is a debilitating voice/speech disorder without an effective cure. To obtain a better understanding of the underlying cortical neural mechanism of the disease we analyzed electroencephalographic (EEG) signals of people with SD during voice production. Method: Ten SD individuals and 10 healthy volunteers produced 50 vowel vocalization epochs of 2500 ms duration. Two EEG features were derived: (1) event-related change in spectral power during vocalization relative to rest, (2) inter-regional spectral coherence. Results: During early vocalization (500–1000 ms) the SD group showed significantly larger alpha band spectral power over the left motor cortex. During late vocalization (1000–2500 ms) SD patients showed a significantly larger gamma band coherence between left somatosensory and premotor cortical areas. Conclusions: Two atypical patterns of cortical activity characterize the pathophysiology of spasmodic dysphonia during voice production: (1) a reduced movement-related desynchronization of motor cortical networks, (2) an excessively large synchronization between left somatosensory and premotor cortical areas. Significance: The pathophysiology of SD is characterized by an abnormally high synchronous activity within and across cortical neural networks involved in voice production that is mainly lateralized in the left hemisphere.

Original language	English (US)
Pages (from-to)	1033-1040
Number of pages	8
Journal	Clinical Neurophysiology
Volume	130
Issue number	6
DOIs	https://doi.org/10.1016/j.clinph.2019.03.003
State	Published - Jun 2019

Bibliographical note

Funding Information:
We appreciate all participants for devoting their time to this study. Our gratitude is extended to the Center for Applied and Translational Sensory Sciences (CATSS), University of Minnesota, for providing the recording space and facilities. This research was supported by NIH 1R21DC011841 to PW and JK and by 1 R01 DC016315-01A1 to JK. No conflicts of interest, financial, or otherwise, are declared by the authors. All authors have approved the final article.

Funding Information:
We appreciate all participants for devoting their time to this study. Our gratitude is extended to the Center for Applied and Translational Sensory Sciences (CATSS) , University of Minnesota, for providing the recording space and facilities. This research was supported by NIH 1R21DC011841 to PW and JK and by 1 R01 DC016315-01A1 to JK.

Publisher Copyright:
© 2019

Keywords

Dystonia
EEG coherence
Larynx
Sensorimotor cortex
Speech
Voice disorder

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10.1016/j.clinph.2019.03.003

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title = "Atypical somatosensory-motor cortical response during vowel vocalization in spasmodic dysphonia",

abstract = "Objective: Spasmodic dysphonia (SD) is a debilitating voice/speech disorder without an effective cure. To obtain a better understanding of the underlying cortical neural mechanism of the disease we analyzed electroencephalographic (EEG) signals of people with SD during voice production. Method: Ten SD individuals and 10 healthy volunteers produced 50 vowel vocalization epochs of 2500 ms duration. Two EEG features were derived: (1) event-related change in spectral power during vocalization relative to rest, (2) inter-regional spectral coherence. Results: During early vocalization (500–1000 ms) the SD group showed significantly larger alpha band spectral power over the left motor cortex. During late vocalization (1000–2500 ms) SD patients showed a significantly larger gamma band coherence between left somatosensory and premotor cortical areas. Conclusions: Two atypical patterns of cortical activity characterize the pathophysiology of spasmodic dysphonia during voice production: (1) a reduced movement-related desynchronization of motor cortical networks, (2) an excessively large synchronization between left somatosensory and premotor cortical areas. Significance: The pathophysiology of SD is characterized by an abnormally high synchronous activity within and across cortical neural networks involved in voice production that is mainly lateralized in the left hemisphere.",

keywords = "Dystonia, EEG coherence, Larynx, Sensorimotor cortex, Speech, Voice disorder",

author = "Sanaz Khosravani and Arash Mahnan and Yeh, {I. Ling} and Watson, {Peter J} and Yang Zhang and George Goding and Juergen Konczak",

note = "Funding Information: We appreciate all participants for devoting their time to this study. Our gratitude is extended to the Center for Applied and Translational Sensory Sciences (CATSS), University of Minnesota, for providing the recording space and facilities. This research was supported by NIH 1R21DC011841 to PW and JK and by 1 R01 DC016315-01A1 to JK. No conflicts of interest, financial, or otherwise, are declared by the authors. All authors have approved the final article. Funding Information: We appreciate all participants for devoting their time to this study. Our gratitude is extended to the Center for Applied and Translational Sensory Sciences (CATSS) , University of Minnesota, for providing the recording space and facilities. This research was supported by NIH 1R21DC011841 to PW and JK and by 1 R01 DC016315-01A1 to JK. Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = jun,

doi = "10.1016/j.clinph.2019.03.003",

language = "English (US)",

volume = "130",

pages = "1033--1040",

journal = "Clinical Neurophysiology",

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T1 - Atypical somatosensory-motor cortical response during vowel vocalization in spasmodic dysphonia

AU - Khosravani, Sanaz

AU - Mahnan, Arash

AU - Yeh, I. Ling

AU - Watson, Peter J

AU - Zhang, Yang

AU - Goding, George

AU - Konczak, Juergen

N1 - Funding Information: We appreciate all participants for devoting their time to this study. Our gratitude is extended to the Center for Applied and Translational Sensory Sciences (CATSS), University of Minnesota, for providing the recording space and facilities. This research was supported by NIH 1R21DC011841 to PW and JK and by 1 R01 DC016315-01A1 to JK. No conflicts of interest, financial, or otherwise, are declared by the authors. All authors have approved the final article. Funding Information: We appreciate all participants for devoting their time to this study. Our gratitude is extended to the Center for Applied and Translational Sensory Sciences (CATSS) , University of Minnesota, for providing the recording space and facilities. This research was supported by NIH 1R21DC011841 to PW and JK and by 1 R01 DC016315-01A1 to JK. Publisher Copyright: © 2019

PY - 2019/6

Y1 - 2019/6

N2 - Objective: Spasmodic dysphonia (SD) is a debilitating voice/speech disorder without an effective cure. To obtain a better understanding of the underlying cortical neural mechanism of the disease we analyzed electroencephalographic (EEG) signals of people with SD during voice production. Method: Ten SD individuals and 10 healthy volunteers produced 50 vowel vocalization epochs of 2500 ms duration. Two EEG features were derived: (1) event-related change in spectral power during vocalization relative to rest, (2) inter-regional spectral coherence. Results: During early vocalization (500–1000 ms) the SD group showed significantly larger alpha band spectral power over the left motor cortex. During late vocalization (1000–2500 ms) SD patients showed a significantly larger gamma band coherence between left somatosensory and premotor cortical areas. Conclusions: Two atypical patterns of cortical activity characterize the pathophysiology of spasmodic dysphonia during voice production: (1) a reduced movement-related desynchronization of motor cortical networks, (2) an excessively large synchronization between left somatosensory and premotor cortical areas. Significance: The pathophysiology of SD is characterized by an abnormally high synchronous activity within and across cortical neural networks involved in voice production that is mainly lateralized in the left hemisphere.

AB - Objective: Spasmodic dysphonia (SD) is a debilitating voice/speech disorder without an effective cure. To obtain a better understanding of the underlying cortical neural mechanism of the disease we analyzed electroencephalographic (EEG) signals of people with SD during voice production. Method: Ten SD individuals and 10 healthy volunteers produced 50 vowel vocalization epochs of 2500 ms duration. Two EEG features were derived: (1) event-related change in spectral power during vocalization relative to rest, (2) inter-regional spectral coherence. Results: During early vocalization (500–1000 ms) the SD group showed significantly larger alpha band spectral power over the left motor cortex. During late vocalization (1000–2500 ms) SD patients showed a significantly larger gamma band coherence between left somatosensory and premotor cortical areas. Conclusions: Two atypical patterns of cortical activity characterize the pathophysiology of spasmodic dysphonia during voice production: (1) a reduced movement-related desynchronization of motor cortical networks, (2) an excessively large synchronization between left somatosensory and premotor cortical areas. Significance: The pathophysiology of SD is characterized by an abnormally high synchronous activity within and across cortical neural networks involved in voice production that is mainly lateralized in the left hemisphere.

KW - Dystonia

KW - EEG coherence

KW - Larynx

KW - Sensorimotor cortex

KW - Speech

KW - Voice disorder

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ER -

Atypical somatosensory-motor cortical response during vowel vocalization in spasmodic dysphonia

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