Atypical hepatic steatosis patterns on MRI after total pancreatectomy with islet autotransplant

Alexandria J. Robbins, Stephen Ritter, Matthew Markese, Mariya E. Skube, Kendall R. McEachron, Melena D. Bellin, Mark J. Stice, Gregory J. Beilman, Robben Schat, Benjamin Spilseth

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE. The purpose of this retrospective study was to investigate the prevalence and patterns of hepatic steatosis after total pancreatectomy with islet autotransplant (TPIAT) and to determine if the unique patterns of steatosis seen in this study correlated with islet graft function. MATERIALS AND METHODS. Fifty-two subjects who had undergone MRI after TPIAT were reviewed for the presence of hepatic steatosis. Patterns of steatosis were categorized into three groups: normal (no steatosis), homogeneous, and atypical. Demographics and outcomes were compared between the groups. Islet graft function 1 year after surgery was classified as full graft function, partial graft function, and graft failure. Statistical analysis was performed using ANOVA, Kruskal-Wallis, and Fisher exact tests. RESULTS. Sixty-three percent of patients had steatosis present on MRI after TPIAT (33 subjects of 52 total), and 48% (25/52) exhibited an atypical pattern. Twenty-four percent of the 37 patients who had MRI examinations before TPIAT showed steatosis preoperatively, yet none of these showed an atypical steatosis pattern. Islet graft function was not statistically different between the groups. The only statistically significant variable difference between the groups was body mass index (p = .02). CONCLUSION. Steatosis is a common finding after TPIAT, and atypical steatosis patterns frequently develop after the procedure, implying that the procedure itself is the causal factor. There was no correlation between islet graft function and the presence or pattern of steatosis. An atypical pattern of hepatic steatosis can therefore be considered an incidental finding after TPIAT and does not require additional workup or treatment.

Original languageEnglish (US)
Pages (from-to)100-106
Number of pages7
JournalAmerican Journal of Roentgenology
Volume217
Issue number1
DOIs
StatePublished - Jul 2021

Bibliographical note

Funding Information:
Supported by grant T32DK108733 from the National Institutes of Health (M. E. Skube and G. J. Beilman) and grant W81X-WH18106872 from the Department of Defense (A. J. Robbins and G. J. Beilman).

Publisher Copyright:
© American Roentgen Ray Society

Keywords

  • Atypical steatosis
  • Hepatic steatosis
  • Islet graft function
  • MRI
  • Total pancreatectomy with islet autotransplant

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

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