Attention and regional cerebral blood flow in posttraumatic stress disorder patients with substance abuse histories

William E. Semple; Peter F. Goyer; Richard McCormick; Beth Compton-Toth; Evan Morris; Beverly Donovan; Gary Muswick; Dennis Nelson; Michelle L. Garnett; James Sharkoff; Greg Leisure; Floro Miraldi; S. Charles Schulz

doi:10.1016/0925-4927(96)02735-7

Attention and regional cerebral blood flow in posttraumatic stress disorder patients with substance abuse histories

William E. Semple, Peter F. Goyer, Richard McCormick, Beth Compton-Toth, Evan Morris, Beverly Donovan, Gary Muswick, Dennis Nelson, Michelle L. Garnett, James Sharkoff, Greg Leisure, Floro Miraldi, S. Charles Schulz

Research output: Contribution to journal › Article › peer-review

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Abstract

Performance on an attentional task was assessed in posttraumatic stress disorder patients with substance abuse histories (PTSD-SA). Positron emission tomography (PET) was used to measure concurrent regional cerebral blood flow (rCBF). Eight male PTSD-SA patients and eight normal subjects each received three serial PET scans with ¹⁵O-labeled water under the following conditions: (1) resting, (2) auditory continuous performance task (ACPT1), and (3) repeat auditory task (ACPT2). PTSD-SA patients made more errors of commission on the ACPT than normal subjects. Examination of right frontal and parietal cortex ACPT task substrates revealed decreased parietal blood flow in PTSD-SA, which may represent a pathophysiology for poor attentional task performance in PTSD-SA. Attentional problems may underlie other symptomatology in PTSD.

Original language	English (US)
Pages (from-to)	17-28
Number of pages	12
Journal	Psychiatry Research - Neuroimaging
Volume	67
Issue number	1
DOIs	https://doi.org/10.1016/0925-4927(96)02735-7
State	Published - May 31 1996
Externally published	Yes

Keywords

Continuous performance task
Parietal cortex
Positron emission tomography

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0925-4927(96)02735-7

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Semple, W. E., Goyer, P. F., McCormick, R., Compton-Toth, B., Morris, E., Donovan, B., Muswick, G., Nelson, D., Garnett, M. L., Sharkoff, J., Leisure, G., Miraldi, F., & Schulz, S. C. (1996). Attention and regional cerebral blood flow in posttraumatic stress disorder patients with substance abuse histories. Psychiatry Research - Neuroimaging, 67(1), 17-28. https://doi.org/10.1016/0925-4927(96)02735-7

Semple, WE, Goyer, PF, McCormick, R, Compton-Toth, B, Morris, E, Donovan, B, Muswick, G, Nelson, D, Garnett, ML, Sharkoff, J, Leisure, G, Miraldi, F & Schulz, SC 1996, 'Attention and regional cerebral blood flow in posttraumatic stress disorder patients with substance abuse histories', Psychiatry Research - Neuroimaging, vol. 67, no. 1, pp. 17-28. https://doi.org/10.1016/0925-4927(96)02735-7

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abstract = "Performance on an attentional task was assessed in posttraumatic stress disorder patients with substance abuse histories (PTSD-SA). Positron emission tomography (PET) was used to measure concurrent regional cerebral blood flow (rCBF). Eight male PTSD-SA patients and eight normal subjects each received three serial PET scans with 15O-labeled water under the following conditions: (1) resting, (2) auditory continuous performance task (ACPT1), and (3) repeat auditory task (ACPT2). PTSD-SA patients made more errors of commission on the ACPT than normal subjects. Examination of right frontal and parietal cortex ACPT task substrates revealed decreased parietal blood flow in PTSD-SA, which may represent a pathophysiology for poor attentional task performance in PTSD-SA. Attentional problems may underlie other symptomatology in PTSD.",

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AU - Morris, Evan

AU - Donovan, Beverly

AU - Muswick, Gary

AU - Nelson, Dennis

AU - Garnett, Michelle L.

AU - Sharkoff, James

AU - Leisure, Greg

AU - Miraldi, Floro

AU - Schulz, S. Charles

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AB - Performance on an attentional task was assessed in posttraumatic stress disorder patients with substance abuse histories (PTSD-SA). Positron emission tomography (PET) was used to measure concurrent regional cerebral blood flow (rCBF). Eight male PTSD-SA patients and eight normal subjects each received three serial PET scans with 15O-labeled water under the following conditions: (1) resting, (2) auditory continuous performance task (ACPT1), and (3) repeat auditory task (ACPT2). PTSD-SA patients made more errors of commission on the ACPT than normal subjects. Examination of right frontal and parietal cortex ACPT task substrates revealed decreased parietal blood flow in PTSD-SA, which may represent a pathophysiology for poor attentional task performance in PTSD-SA. Attentional problems may underlie other symptomatology in PTSD.

KW - Continuous performance task

KW - Parietal cortex

KW - Positron emission tomography

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Attention and regional cerebral blood flow in posttraumatic stress disorder patients with substance abuse histories

Abstract

Keywords

UN SDGs

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