Attention and corpus callosum volumes in individuals with mucopolysaccharidosis type I

Kelly E King, Kyle Rudser, Igor Nestrasil, Victor Kovac, Kathleen A. Delaney, Jeffrey R Wozniak, Bryon A Mueller, Kelvin O Lim, Julie Eisengart, Eva G. Mamak, Julian Raiman, Nadia Ali, Stephanie Cagle, Paul Harmatz, Chester B Whitley, Elsa G. Shapiro

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Previous research suggests attention and white matter (WM) abnormalities in individuals with mucopolysaccharidosis type I (MPS I); this cross-sectional comparison is one of the first to examine the relationship of WM structural abnormalities as measured by corpus callosum (CC) volumes with attention scores to evaluate this relationship in a larger sample of patients with MPS I. METHODS: Volumetric MRI data and performance on a computerized measure of sustained attention were compared for 18 participants with the severe form of MPS I (MPS IH), 18 participants with the attenuated form of MPS I (MPS IATT), and 60 typically developing age-matched controls. RESULTS: The MPS I groups showed below-average mean attention scores (p < 0.001) and smaller CC volumes (p < 0.001) than controls. No significant associations were found between attention performance and CC volume for controls. Attention was associated with posterior CC volumes in the participants with MPS IH (p = 0.053) and total (p = 0.007) and anterior (p < 0.001) CC volumes in participants with MPS IATT. CONCLUSIONS: We found that attention and CC volumes were reduced in participants with MPS I compared to typically developing controls. Smaller CC volumes in participants with MPS I were associated with decreased attention; such an association was not seen in controls. While hematopoietic cell transplantation used to treat MPS IH may compound these effects, attention difficulties were also seen in the MPS IATT group, suggesting that disease effects contribute substantially to the clinical attentional difficulties seen in this population.

Original languageEnglish (US)
Pages (from-to)e2321-e2328
JournalNeurology
Volume92
Issue number20
DOIs
StatePublished - May 14 2019
Externally publishedYes

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Mucopolysaccharidosis I
Corpus Callosum
Cell Transplantation
Research

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Attention and corpus callosum volumes in individuals with mucopolysaccharidosis type I. / King, Kelly E; Rudser, Kyle; Nestrasil, Igor; Kovac, Victor; Delaney, Kathleen A.; Wozniak, Jeffrey R; Mueller, Bryon A; Lim, Kelvin O; Eisengart, Julie; Mamak, Eva G.; Raiman, Julian; Ali, Nadia; Cagle, Stephanie; Harmatz, Paul; Whitley, Chester B; Shapiro, Elsa G.

In: Neurology, Vol. 92, No. 20, 14.05.2019, p. e2321-e2328.

Research output: Contribution to journalArticle

King, Kelly E ; Rudser, Kyle ; Nestrasil, Igor ; Kovac, Victor ; Delaney, Kathleen A. ; Wozniak, Jeffrey R ; Mueller, Bryon A ; Lim, Kelvin O ; Eisengart, Julie ; Mamak, Eva G. ; Raiman, Julian ; Ali, Nadia ; Cagle, Stephanie ; Harmatz, Paul ; Whitley, Chester B ; Shapiro, Elsa G. / Attention and corpus callosum volumes in individuals with mucopolysaccharidosis type I. In: Neurology. 2019 ; Vol. 92, No. 20. pp. e2321-e2328.
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title = "Attention and corpus callosum volumes in individuals with mucopolysaccharidosis type I",
abstract = "OBJECTIVE: Previous research suggests attention and white matter (WM) abnormalities in individuals with mucopolysaccharidosis type I (MPS I); this cross-sectional comparison is one of the first to examine the relationship of WM structural abnormalities as measured by corpus callosum (CC) volumes with attention scores to evaluate this relationship in a larger sample of patients with MPS I. METHODS: Volumetric MRI data and performance on a computerized measure of sustained attention were compared for 18 participants with the severe form of MPS I (MPS IH), 18 participants with the attenuated form of MPS I (MPS IATT), and 60 typically developing age-matched controls. RESULTS: The MPS I groups showed below-average mean attention scores (p < 0.001) and smaller CC volumes (p < 0.001) than controls. No significant associations were found between attention performance and CC volume for controls. Attention was associated with posterior CC volumes in the participants with MPS IH (p = 0.053) and total (p = 0.007) and anterior (p < 0.001) CC volumes in participants with MPS IATT. CONCLUSIONS: We found that attention and CC volumes were reduced in participants with MPS I compared to typically developing controls. Smaller CC volumes in participants with MPS I were associated with decreased attention; such an association was not seen in controls. While hematopoietic cell transplantation used to treat MPS IH may compound these effects, attention difficulties were also seen in the MPS IATT group, suggesting that disease effects contribute substantially to the clinical attentional difficulties seen in this population.",
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TY - JOUR

T1 - Attention and corpus callosum volumes in individuals with mucopolysaccharidosis type I

AU - King, Kelly E

AU - Rudser, Kyle

AU - Nestrasil, Igor

AU - Kovac, Victor

AU - Delaney, Kathleen A.

AU - Wozniak, Jeffrey R

AU - Mueller, Bryon A

AU - Lim, Kelvin O

AU - Eisengart, Julie

AU - Mamak, Eva G.

AU - Raiman, Julian

AU - Ali, Nadia

AU - Cagle, Stephanie

AU - Harmatz, Paul

AU - Whitley, Chester B

AU - Shapiro, Elsa G.

PY - 2019/5/14

Y1 - 2019/5/14

N2 - OBJECTIVE: Previous research suggests attention and white matter (WM) abnormalities in individuals with mucopolysaccharidosis type I (MPS I); this cross-sectional comparison is one of the first to examine the relationship of WM structural abnormalities as measured by corpus callosum (CC) volumes with attention scores to evaluate this relationship in a larger sample of patients with MPS I. METHODS: Volumetric MRI data and performance on a computerized measure of sustained attention were compared for 18 participants with the severe form of MPS I (MPS IH), 18 participants with the attenuated form of MPS I (MPS IATT), and 60 typically developing age-matched controls. RESULTS: The MPS I groups showed below-average mean attention scores (p < 0.001) and smaller CC volumes (p < 0.001) than controls. No significant associations were found between attention performance and CC volume for controls. Attention was associated with posterior CC volumes in the participants with MPS IH (p = 0.053) and total (p = 0.007) and anterior (p < 0.001) CC volumes in participants with MPS IATT. CONCLUSIONS: We found that attention and CC volumes were reduced in participants with MPS I compared to typically developing controls. Smaller CC volumes in participants with MPS I were associated with decreased attention; such an association was not seen in controls. While hematopoietic cell transplantation used to treat MPS IH may compound these effects, attention difficulties were also seen in the MPS IATT group, suggesting that disease effects contribute substantially to the clinical attentional difficulties seen in this population.

AB - OBJECTIVE: Previous research suggests attention and white matter (WM) abnormalities in individuals with mucopolysaccharidosis type I (MPS I); this cross-sectional comparison is one of the first to examine the relationship of WM structural abnormalities as measured by corpus callosum (CC) volumes with attention scores to evaluate this relationship in a larger sample of patients with MPS I. METHODS: Volumetric MRI data and performance on a computerized measure of sustained attention were compared for 18 participants with the severe form of MPS I (MPS IH), 18 participants with the attenuated form of MPS I (MPS IATT), and 60 typically developing age-matched controls. RESULTS: The MPS I groups showed below-average mean attention scores (p < 0.001) and smaller CC volumes (p < 0.001) than controls. No significant associations were found between attention performance and CC volume for controls. Attention was associated with posterior CC volumes in the participants with MPS IH (p = 0.053) and total (p = 0.007) and anterior (p < 0.001) CC volumes in participants with MPS IATT. CONCLUSIONS: We found that attention and CC volumes were reduced in participants with MPS I compared to typically developing controls. Smaller CC volumes in participants with MPS I were associated with decreased attention; such an association was not seen in controls. While hematopoietic cell transplantation used to treat MPS IH may compound these effects, attention difficulties were also seen in the MPS IATT group, suggesting that disease effects contribute substantially to the clinical attentional difficulties seen in this population.

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U2 - 10.1212/WNL.0000000000007496

DO - 10.1212/WNL.0000000000007496

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JO - Neurology

JF - Neurology

SN - 0028-3878

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