Attention and corpus callosum volumes in individuals with mucopolysaccharidosis type i

Kelly E. King, Kyle D. Rudser, Igor Nestrasil, Victor Kovac, Kathleen A. Delaney, Jeffrey R. Wozniak, Bryon A. Mueller, Kelvin O. Lim, Julie B. Eisengart, Eva G. Mamak, Julian Raiman, Nadia Ali, Stephanie Cagle, Paul Harmatz, Chester B. Whitley, Elsa G. Shapiro

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Abstract

Objective Previous research suggests attention and white matter (WM) abnormalities in individuals with mucopolysaccharidosis type I (MPS I); this cross-sectional comparison is one of the first to examine the relationship of WM structural abnormalities as measured by corpus callosum (CC) volumes with attention scores to evaluate this relationship in a larger sample of patients with MPS I.MethodsVolumetric MRI data and performance on a computerized measure of sustained attention were compared for 18 participants with the severe form of MPS I (MPS IH), 18 participants with the attenuated form of MPS I (MPS IATT), and 60 typically developing age-matched controls.ResultsThe MPS I groups showed below-average mean attention scores (p < 0.001) and smaller CC volumes (p < 0.001) than controls. No significant associations were found between attention performance and CC volume for controls. Attention was associated with posterior CC volumes in the participants with MPS IH (p = 0.053) and total (p = 0.007) and anterior (p < 0.001) CC volumes in participants with MPS IATT.ConclusionsWe found that attention and CC volumes were reduced in participants with MPS I compared to typically developing controls. Smaller CC volumes in participants with MPS I were associated with decreased attention; such an association was not seen in controls. While hematopoietic cell transplantation used to treat MPS IH may compound these effects, attention difficulties were also seen in the MPS IATT group, suggesting that disease effects contribute substantially to the clinical attentional difficulties seen in this population.

Original languageEnglish (US)
Pages (from-to)E2321-E2328
JournalNeurology
Volume92
Issue number20
DOIs
StatePublished - May 14 2019

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Mucopolysaccharidoses
Mucopolysaccharidosis I
Corpus Callosum
Cell Transplantation
Research

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Attention and corpus callosum volumes in individuals with mucopolysaccharidosis type i. / King, Kelly E.; Rudser, Kyle D.; Nestrasil, Igor; Kovac, Victor; Delaney, Kathleen A.; Wozniak, Jeffrey R.; Mueller, Bryon A.; Lim, Kelvin O.; Eisengart, Julie B.; Mamak, Eva G.; Raiman, Julian; Ali, Nadia; Cagle, Stephanie; Harmatz, Paul; Whitley, Chester B.; Shapiro, Elsa G.

In: Neurology, Vol. 92, No. 20, 14.05.2019, p. E2321-E2328.

Research output: Contribution to journalArticle

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title = "Attention and corpus callosum volumes in individuals with mucopolysaccharidosis type i",
abstract = "Objective Previous research suggests attention and white matter (WM) abnormalities in individuals with mucopolysaccharidosis type I (MPS I); this cross-sectional comparison is one of the first to examine the relationship of WM structural abnormalities as measured by corpus callosum (CC) volumes with attention scores to evaluate this relationship in a larger sample of patients with MPS I.MethodsVolumetric MRI data and performance on a computerized measure of sustained attention were compared for 18 participants with the severe form of MPS I (MPS IH), 18 participants with the attenuated form of MPS I (MPS IATT), and 60 typically developing age-matched controls.ResultsThe MPS I groups showed below-average mean attention scores (p < 0.001) and smaller CC volumes (p < 0.001) than controls. No significant associations were found between attention performance and CC volume for controls. Attention was associated with posterior CC volumes in the participants with MPS IH (p = 0.053) and total (p = 0.007) and anterior (p < 0.001) CC volumes in participants with MPS IATT.ConclusionsWe found that attention and CC volumes were reduced in participants with MPS I compared to typically developing controls. Smaller CC volumes in participants with MPS I were associated with decreased attention; such an association was not seen in controls. While hematopoietic cell transplantation used to treat MPS IH may compound these effects, attention difficulties were also seen in the MPS IATT group, suggesting that disease effects contribute substantially to the clinical attentional difficulties seen in this population.",
author = "King, {Kelly E.} and Rudser, {Kyle D.} and Igor Nestrasil and Victor Kovac and Delaney, {Kathleen A.} and Wozniak, {Jeffrey R.} and Mueller, {Bryon A.} and Lim, {Kelvin O.} and Eisengart, {Julie B.} and Mamak, {Eva G.} and Julian Raiman and Nadia Ali and Stephanie Cagle and Paul Harmatz and Whitley, {Chester B.} and Shapiro, {Elsa G.}",
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T1 - Attention and corpus callosum volumes in individuals with mucopolysaccharidosis type i

AU - King, Kelly E.

AU - Rudser, Kyle D.

AU - Nestrasil, Igor

AU - Kovac, Victor

AU - Delaney, Kathleen A.

AU - Wozniak, Jeffrey R.

AU - Mueller, Bryon A.

AU - Lim, Kelvin O.

AU - Eisengart, Julie B.

AU - Mamak, Eva G.

AU - Raiman, Julian

AU - Ali, Nadia

AU - Cagle, Stephanie

AU - Harmatz, Paul

AU - Whitley, Chester B.

AU - Shapiro, Elsa G.

PY - 2019/5/14

Y1 - 2019/5/14

N2 - Objective Previous research suggests attention and white matter (WM) abnormalities in individuals with mucopolysaccharidosis type I (MPS I); this cross-sectional comparison is one of the first to examine the relationship of WM structural abnormalities as measured by corpus callosum (CC) volumes with attention scores to evaluate this relationship in a larger sample of patients with MPS I.MethodsVolumetric MRI data and performance on a computerized measure of sustained attention were compared for 18 participants with the severe form of MPS I (MPS IH), 18 participants with the attenuated form of MPS I (MPS IATT), and 60 typically developing age-matched controls.ResultsThe MPS I groups showed below-average mean attention scores (p < 0.001) and smaller CC volumes (p < 0.001) than controls. No significant associations were found between attention performance and CC volume for controls. Attention was associated with posterior CC volumes in the participants with MPS IH (p = 0.053) and total (p = 0.007) and anterior (p < 0.001) CC volumes in participants with MPS IATT.ConclusionsWe found that attention and CC volumes were reduced in participants with MPS I compared to typically developing controls. Smaller CC volumes in participants with MPS I were associated with decreased attention; such an association was not seen in controls. While hematopoietic cell transplantation used to treat MPS IH may compound these effects, attention difficulties were also seen in the MPS IATT group, suggesting that disease effects contribute substantially to the clinical attentional difficulties seen in this population.

AB - Objective Previous research suggests attention and white matter (WM) abnormalities in individuals with mucopolysaccharidosis type I (MPS I); this cross-sectional comparison is one of the first to examine the relationship of WM structural abnormalities as measured by corpus callosum (CC) volumes with attention scores to evaluate this relationship in a larger sample of patients with MPS I.MethodsVolumetric MRI data and performance on a computerized measure of sustained attention were compared for 18 participants with the severe form of MPS I (MPS IH), 18 participants with the attenuated form of MPS I (MPS IATT), and 60 typically developing age-matched controls.ResultsThe MPS I groups showed below-average mean attention scores (p < 0.001) and smaller CC volumes (p < 0.001) than controls. No significant associations were found between attention performance and CC volume for controls. Attention was associated with posterior CC volumes in the participants with MPS IH (p = 0.053) and total (p = 0.007) and anterior (p < 0.001) CC volumes in participants with MPS IATT.ConclusionsWe found that attention and CC volumes were reduced in participants with MPS I compared to typically developing controls. Smaller CC volumes in participants with MPS I were associated with decreased attention; such an association was not seen in controls. While hematopoietic cell transplantation used to treat MPS IH may compound these effects, attention difficulties were also seen in the MPS IATT group, suggesting that disease effects contribute substantially to the clinical attentional difficulties seen in this population.

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