Attachment and growth of mammalian cells on microcarriers with different ion exchange capacities

Vaughn B. Himes, Wei-Shou Hu

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

In the design of microcarriers for animal cell growth, the exchange capacity has been considered a critical factor. However, charge densities of microcarriers under culture conditions are not the same as the exchange capacities. Furthermore, the charge density requirement for optimum attachment is not necessarily the same as that required for optimum growth. We demonstrate that charge is not the sole factor affecting the attachment and growth of animal cells on microcarriers. We also show that supplemental serum in the growth medium has a negative effect on cell attachment to microcarriers.

Original languageEnglish (US)
Pages (from-to)1155-1163
Number of pages9
JournalBiotechnology and Bioengineering
Volume29
Issue number9
DOIs
StatePublished - Jun 20 1987

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