Atrial fibrillation: Defining potential curative ablation targets

David G Benditt, Nemer Samniah, Gerard J. Fahy, Keith G Lurie, Scott Sakaguchi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The concept that atrial fibrillation (or at least certain forms of the arrhythmia) may be amenable to reversal or amelioration by transcatheter ablation techniques has become increasingly accepted in recent years. As yet, however, the techniques being studied for ablation of atrial fibrillation address neither known critical anatomic elements nor well defined electrophysiologic markers. The approaches, although essentially empirical, are conceptually based on the 'multiple wavelet' or 'focal origin' hypotheses. To date, addressing 'focal origin' atrial fibrillation by transcatheter ablation has been the more encouraging. However, as technology evolves, both in terms of catheter design and possibly endocardial mapping techniques, approaches to wavelet or rotor mechanisms may become similarly effective. This communication examines concepts regarding the manner in which atrial fibrillation is initiated and maintained. The goal is to better understand the encouraging success of empirical ablation methods, and possibly derive insights which may help refine ablation targeting in the future.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalJournal of Interventional Cardiac Electrophysiology
Issue numberSUPPL. 1
StatePublished - 2000

Bibliographical note

Funding Information:
Dr. Samniah is supported by a grant from the Midwest Arrhythmia Research Foundation Address for correspondence: David G Benditt, M.D., Box 508 FUMC, Minneapolis, MN, 55455. Tel: (612) 625-4401; Fax: (612) 624-4937


  • Ablation
  • Atrial fibrillation
  • Focal origin
  • Reentry


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