ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop

Dominick A. Matos; Jia Min Zhang; Jian Ouyang; Hai Dang Nguyen; Marie Michelle Genois; Lee Zou

doi:10.1016/j.molcel.2019.10.010

ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop

Dominick A. Matos, Jia Min Zhang, Jian Ouyang, Hai Dang Nguyen, Marie Michelle Genois, Lee Zou

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

R loops cause genomic instability, but how cells respond to R loop-associated genomic stress is poorly understood. Matos et al. show that the ATR-Chk1 pathway senses R loop-impeded replication forks through a MUS81-mediated mechanism and protects replication forks from excessive MUS81 cleavage, revealing a MUS81-triggered and ATR-mediated feedback loop safeguarding the genome against R loops.

Original language	English (US)
Pages (from-to)	514-527.e4
Journal	Molecular Cell
Volume	77
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2019.10.010
State	Published - Feb 6 2020
Externally published	Yes

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Keywords

ATR
Chk1
Fork reversal
Genomic Instability
MUS81
R loop
checkpoint

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Cite this

Matos, D. A., Zhang, J. M., Ouyang, J., Nguyen, H. D., Genois, M. M., & Zou, L. (2020). ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop. Molecular Cell, 77(3), 514-527.e4. https://doi.org/10.1016/j.molcel.2019.10.010

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AU - Genois, Marie Michelle

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Access

10.1016/j.molcel.2019.10.010