ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop

Dominick A. Matos, Jia Min Zhang, Jian Ouyang, Hai Dang Nguyen, Marie Michelle Genois, Lee Zou

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

R loops cause genomic instability, but how cells respond to R loop-associated genomic stress is poorly understood. Matos et al. show that the ATR-Chk1 pathway senses R loop-impeded replication forks through a MUS81-mediated mechanism and protects replication forks from excessive MUS81 cleavage, revealing a MUS81-triggered and ATR-mediated feedback loop safeguarding the genome against R loops.

Original languageEnglish (US)
Pages (from-to)514-527.e4
JournalMolecular Cell
Volume77
Issue number3
DOIs
StatePublished - Feb 6 2020
Externally publishedYes

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Keywords

  • ATR
  • Chk1
  • Fork reversal
  • Genomic Instability
  • MUS81
  • R loop
  • checkpoint

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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