Atopic dermatitis: Update for pediatricians

Katherine Grey, Sheilagh Maguiness

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder present in up to 20% of children. Recent advances implicate skin barrier dysfunction as central to disease pathogenesis. Genetic defects in the filaggrin gene, the product of which is important for maintaining the epidermal barrier, are a strong predisposing factor in the development of AD. In addition to reducing identifiable triggers, treatment should focus on the four clinical characteristics of eczema: emollients for dry skin, topical anti-inflammatory agents to reduce inflammation and itch, and strategies to reduce infection/colonization, which can include diluted bleach baths. New studies demonstrate that early emollient application from birth may prevent development of AD.

Original languageEnglish (US)
Pages (from-to)e280-e286
JournalPediatric annals
Volume45
Issue number8
DOIs
StatePublished - Aug 2016

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