Asystole complicating physostigmine treatment of tricyclic antidepressant overdose

Paul Pentel, Charles D. Peterson

Research output: Contribution to journalArticlepeer-review

161 Scopus citations


Physostigmine is a commonly used therapy for the anticholinergic manifestations of tricyclic antidepressant (TCA) overdose. We describe two patients with TCA toxicity who developed asystole following the administration of physostigmine to treat seizures.

Original languageEnglish (US)
Pages (from-to)588-590
Number of pages3
JournalAnnals of Emergency Medicine
Issue number11
StatePublished - Jan 1 1980


  • asystole, complication of physostigmine use
  • overdose, tricyclic antidepressant, treatment with physostigmine
  • physostigmine, for tricyclic antidepressant overdose, asystole complicating
  • tricyclic antidepressant overdose, treatment with physostigmine, asystole complicating


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