Asynchronous computation with molecular reactions

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Mass-action kinetics of chemical reaction networks (CRNs) is powerful to describe computations through transfers of chemical concentrations. Here we present methods for asynchronously implementing digital signal processing (DSP) operations such as filtering with CRNs. We first review an implementation of DSP operations using molecular reactions based on a three-phase transfer scheme. This is an example of a locally asynchronous, globally synchronous implementation. We then present a fully asynchronous method that transfers signals based on absence of other signals. We illustrate our methodology with the design of finite impulse response (FIR) filters. The computation is exact and independent of specific reaction rates. Although conceptual for the time being, the proposed methodology has potential applications in domains of synthetic biology such as biochemical sensing and drug delivery.

Original languageEnglish (US)
Title of host publicationConference Record of the 45th Asilomar Conference on Signals, Systems and Computers, ASILOMAR 2011
Pages493-497
Number of pages5
DOIs
StatePublished - Dec 1 2011
Event45th Asilomar Conference on Signals, Systems and Computers, ASILOMAR 2011 - Pacific Grove, CA, United States
Duration: Nov 6 2011Nov 9 2011

Publication series

NameConference Record - Asilomar Conference on Signals, Systems and Computers
ISSN (Print)1058-6393

Other

Other45th Asilomar Conference on Signals, Systems and Computers, ASILOMAR 2011
CountryUnited States
CityPacific Grove, CA
Period11/6/1111/9/11

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    Jiang, H., Riedel, M., & Parhi, K. K. (2011). Asynchronous computation with molecular reactions. In Conference Record of the 45th Asilomar Conference on Signals, Systems and Computers, ASILOMAR 2011 (pp. 493-497). [6190049] (Conference Record - Asilomar Conference on Signals, Systems and Computers). https://doi.org/10.1109/ACSSC.2011.6190049