Asymptomatic intracranial aneurysms in beta-thalassemia: A three-year follow-up report

Renzo Manara, Martina Caiazza, Rosanna Di Concilio, Angela Ciancio, Elisa De Michele, Caterina Maietta, Daniela Capalbo, Camilla Russo, Domenico Roberti, Maddalena Casale, Andrea Elefante, Fabrizio Esposito, Sara Ponticorvo, Andrea Gerardo Russo, Antonietta Canna, Mario Cirillo, Silverio Perrotta, Immacolata Tartaglione

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: No information is currently available regarding the natural history of asymptomatic intracranial aneurysms in beta-thalassemia, raising several concerns about their proper management. Methods: We performed a prospective longitudinal three-year-long MR-angiography study on nine beta-thalassemia patients (mean-age 40.3 ± 7.5, six females, 8 transfusion dependent) harboring ten asymptomatic intracranial aneurysms. In addition, we analyzed the clinical files of all adult beta-thalassemia patients (160 patients including those followed with MR-angiography, 121 transfusion dependent) referring to our Centers between 2014 and 2019 searching for history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Results: At the end of the three-year-long follow-up, no patient showed any change in the size and shape of the aneurysms, none presented new intracranial aneurysms or artery stenoses, none showed new brain vascular-like parenchymal lesions or enlargement of the preexisting ones. Besides, in our database of all adult beta-thalassemia patients, no one had history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Conclusions: Incidental asymptomatic intracranial aneurysms do not seem to be associated, in beta-thalassemia, with an increased risk of complications (enlargement or rupture) at least in the short term period, helping to optimize human and economic resources and patient compliance during their complex long-lasting management.

Original languageEnglish (US)
Article number21
JournalOrphanet Journal of Rare Diseases
Issue number1
StatePublished - Jan 20 2020
Externally publishedYes

Bibliographical note

Funding Information:
Financial support was provided by Programma VALERE (VAnviteLli pEr la RicErca), Università della Campania “L. Vanvitelli”, Naples, Italy (SP).

Publisher Copyright:
© 2020 The Author(s).


  • Aneurysm
  • Beta-thalassemia
  • Magnetic resonance angiography
  • Subarachnoid hemorrhage


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