Asymptomatic Clostridium difficile colonization as a reservoir for Clostridium difficile infection

Alison L. Galdys, Scott R. Curry, Lee H. Harrison

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Clostridium difficile (CD) infection (CDI) is the leading cause of healthcare associated diarrhea despite intense hospital infection prevention programs. A substantial proportion of the population is asymptomatically colonized with CD, and evidence is mounting that these individuals serve as a reservoir for CDI. The purpose of this review is to discuss the mechanisms by which individuals may harbor toxigenic CD but remain asymptomatic, the evidence that asymptomatically colonized individuals serve as a source of CDI, and the implications of this potential CD reservoir for healthcare infection prevention.

Original languageEnglish (US)
Pages (from-to)967-980
Number of pages14
JournalExpert Review of Anti-Infective Therapy
Volume12
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • Clostridium difficile
  • Clostridium difficile infection
  • asymptomatic carriage
  • colonization
  • epidemiology
  • molecular epidemiology

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