Asymmetric synthesis of (+)-tetrahydropseudodistomin

S. Chandrasekhar, S. Shameem Sultana, N. Kiranmai, Ch Narsihmulu

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11 Scopus citations

Abstract

An efficient asymmetric synthesis of (+)-tetrahydropseudodistomin is described. The important synthetic features include a Maruoka asymmetric allylation and a Sharpless asymmetric dihydroxylation as key steps for the generation of chirality at C-2, -4, and -5 of the trisubstituted piperidine ring.

Original languageEnglish (US)
Pages (from-to)2373-2375
Number of pages3
JournalTetrahedron Letters
Volume48
Issue number13
DOIs
StatePublished - Mar 26 2007
Externally publishedYes

Bibliographical note

Funding Information:
S.S.S. thanks the CSIR, New Delhi and N.K. thanks the UGC, New Delhi, for financial support and S.C. thanks the DST, New Delhi, for a grant.

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

Keywords

  • Marouka asymmetric allylation
  • Sharpless asymmetric dihydroxylation

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