Asymmetric N-heterocyclic carbene (NHC)-catalyzed annulation of modified enals with enolizable aldehydes

Santhivardhana Reddy Yetra; Trinadh Kaicharla; Sunita S. Kunte; Rajesh G. Gonnade; Akkattu T. Biju

doi:10.1021/ol4026155

Asymmetric N-heterocyclic carbene (NHC)-catalyzed annulation of modified enals with enolizable aldehydes

Santhivardhana Reddy Yetra, Trinadh Kaicharla, Sunita S. Kunte, Rajesh G. Gonnade, Akkattu T. Biju

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

N-Heterocyclic carbene (NHC)-catalyzed highly enantioselective lactonization of modified enals with enolizable aldehydes, proceeding via the α,β-unsaturated acylazolium intermediates, is reported. The reaction results in the asymmetric synthesis of synthetically important 4,5-disubstituted dihydropyranones.

Original language	English (US)
Pages (from-to)	5202-5205
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	20
DOIs	https://doi.org/10.1021/ol4026155
State	Published - Oct 18 2013
Externally published	Yes

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10.1021/ol4026155

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title = "Asymmetric N-heterocyclic carbene (NHC)-catalyzed annulation of modified enals with enolizable aldehydes",

abstract = "N-Heterocyclic carbene (NHC)-catalyzed highly enantioselective lactonization of modified enals with enolizable aldehydes, proceeding via the α,β-unsaturated acylazolium intermediates, is reported. The reaction results in the asymmetric synthesis of synthetically important 4,5-disubstituted dihydropyranones.",

author = "Yetra, {Santhivardhana Reddy} and Trinadh Kaicharla and Kunte, {Sunita S.} and Gonnade, {Rajesh G.} and Biju, {Akkattu T.}",

year = "2013",

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doi = "10.1021/ol4026155",

language = "English (US)",

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journal = "Organic Letters",

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T1 - Asymmetric N-heterocyclic carbene (NHC)-catalyzed annulation of modified enals with enolizable aldehydes

AU - Yetra, Santhivardhana Reddy

AU - Kaicharla, Trinadh

AU - Kunte, Sunita S.

AU - Gonnade, Rajesh G.

AU - Biju, Akkattu T.

PY - 2013/10/18

Y1 - 2013/10/18

N2 - N-Heterocyclic carbene (NHC)-catalyzed highly enantioselective lactonization of modified enals with enolizable aldehydes, proceeding via the α,β-unsaturated acylazolium intermediates, is reported. The reaction results in the asymmetric synthesis of synthetically important 4,5-disubstituted dihydropyranones.

AB - N-Heterocyclic carbene (NHC)-catalyzed highly enantioselective lactonization of modified enals with enolizable aldehydes, proceeding via the α,β-unsaturated acylazolium intermediates, is reported. The reaction results in the asymmetric synthesis of synthetically important 4,5-disubstituted dihydropyranones.

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M3 - Article

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JO - Organic Letters

JF - Organic Letters

IS - 20

ER -

Asymmetric N-heterocyclic carbene (NHC)-catalyzed annulation of modified enals with enolizable aldehydes

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