TY - JOUR
T1 - Asymmetric Hypsarrhythmia
T2 - Clinical Electroencephalographic and Radiological Findings
AU - Drury, Ivo
AU - Beydoun, Ahmad
AU - Garofalo, Elizabeth A.
AU - Henry, Thomas R.
PY - 1995/1
Y1 - 1995/1
N2 - Summary: Twenty‐six children (16 boys and 10 girls) with hypsarrhythmia and infantile spasms (IS) were studied at the University of Michigan EEG Laboratory in a 4‐year period. Six (2 boys, 4 girls), had asymmetric hypsarrhythmia with a preponderance of both slowing and epileptic form activity over one hemisphere. All 6 had the symptomatic form of IS, 4 with dysplastic conditions, 1 with porencephaly from a cerebral infarct, and 1 with hypoxic‐ischemic encephalopathy. Five children had focal abnormalities on either physical examination or imaging studies. Four had the highest amplitude slowing and most epileptiform activity ipsilateral to the lesion, in 1, it was contralateral. Asymmetric hypsarrhythmia constituted 23% of cases with hypsarrhythmia examined at our EEG laboratory. The significant success in surgical therapy for some children with IS indicates the importance of identifying focal hemispheric abnormalities even if they are not apparent clinically. EEG may suggest focal changes not detected clinically or radiologically.
AB - Summary: Twenty‐six children (16 boys and 10 girls) with hypsarrhythmia and infantile spasms (IS) were studied at the University of Michigan EEG Laboratory in a 4‐year period. Six (2 boys, 4 girls), had asymmetric hypsarrhythmia with a preponderance of both slowing and epileptic form activity over one hemisphere. All 6 had the symptomatic form of IS, 4 with dysplastic conditions, 1 with porencephaly from a cerebral infarct, and 1 with hypoxic‐ischemic encephalopathy. Five children had focal abnormalities on either physical examination or imaging studies. Four had the highest amplitude slowing and most epileptiform activity ipsilateral to the lesion, in 1, it was contralateral. Asymmetric hypsarrhythmia constituted 23% of cases with hypsarrhythmia examined at our EEG laboratory. The significant success in surgical therapy for some children with IS indicates the importance of identifying focal hemispheric abnormalities even if they are not apparent clinically. EEG may suggest focal changes not detected clinically or radiologically.
KW - Asymmetric hypsarrhythmia
KW - Cerebral dysgenesis–Therapeutic implications
KW - Children
KW - Infantile spasms Electroencephalographic criteria
KW - Neuroimaging
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U2 - 10.1111/j.1528-1157.1995.tb01663.x
DO - 10.1111/j.1528-1157.1995.tb01663.x
M3 - Article
C2 - 8001507
AN - SCOPUS:0028855802
SN - 0013-9580
VL - 36
SP - 41
EP - 47
JO - Epilepsia
JF - Epilepsia
IS - 1
ER -