Abstract
Spirocycles provide an exciting platform to develop and understand the reactivity and selectivity for a wide variety of catalysts while affording diverse strategies to access molecules with important applications. This review features recent examples in which a spirocenter is formed within the key step of a catalytic asymmetric process, in either an intramolecular or intermolecular fashion. Examples highlight notable spirocyclization strategies and compare the reactivity and selectivity for different classes of chiral organocatalysts and organometallic catalysts.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 540-553 |
| Number of pages | 14 |
| Journal | ACS Catalysis |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 5 2013 |
Keywords
- asymmetric
- catalytic
- spirocenter
- spirocyclic
- spiroketals
- spirolactones
- spirooxindole