Asymmetric catalysis for the synthesis of spirocyclic compounds

Annaliese K. Franz, Nadine V. Hanhan, Nicolas R. Ball-Jones

Research output: Contribution to journalReview articlepeer-review

190 Scopus citations


Spirocycles provide an exciting platform to develop and understand the reactivity and selectivity for a wide variety of catalysts while affording diverse strategies to access molecules with important applications. This review features recent examples in which a spirocenter is formed within the key step of a catalytic asymmetric process, in either an intramolecular or intermolecular fashion. Examples highlight notable spirocyclization strategies and compare the reactivity and selectivity for different classes of chiral organocatalysts and organometallic catalysts.

Original languageEnglish (US)
Pages (from-to)540-553
Number of pages14
JournalACS Catalysis
Issue number4
StatePublished - Apr 5 2013


  • asymmetric
  • catalytic
  • spirocenter
  • spirocyclic
  • spiroketals
  • spirolactones
  • spirooxindole

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