Asymmetric aldol reactions in poly(ethylene glycol) catalyzed by L-proline

S. Chandrasekhar, Ch Narsihmulu, N. Ramakrishna Reddy, S. Shameem Sultana

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


A rapid L-proline catalyzed direct aldol reaction between various aldehydes and acetone was achieved using PEG as the solvent with comparable enantioselectivities and yields to those obtained in other solvents. Recycling the catalyst and solvent (PEG) was possible 10 times without loss of activity.

Original languageEnglish (US)
Pages (from-to)4581-4582
Number of pages2
JournalTetrahedron Letters
Issue number23
StatePublished - May 31 2004
Externally publishedYes

Bibliographical note

Funding Information:
We C.N., N.R.K. and S.S.S. thank CSIR New Delhi for financial support.


  • Asymmetric aldol reaction
  • L-Proline
  • PEG
  • Reusability


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