Astrocytes in endocannabinoid signalling

Marta Navarrete, Adolfo Díez, Alfonso Araque

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations


Astrocytes are emerging as integral functional components of synapses, responding to synaptically released neurotransmitters and regulating synaptic transmission and plasticity. Thus, they functionally interact with neurons establishing tripartite synapses: a functional concept that refers to the existence of communication between astrocytes and neurons and its crucial role in synaptic function. Here, we discuss recent evidence showing that astrocytes are involved in the endocannabinoid (ECB) system, responding to exogenous cannabinoids as well as ECBs through activation of type 1 cannabinoid receptors, which increase intracellular calcium and stimulate the release of glutamate that modulates synaptic transmission and plasticity. We also discuss the consequences of ECB signalling in tripartite synapses on the astrocyte-mediated regulation of synaptic function, which reveal novel properties of synaptic regulation by ECBs, such as the spatially controlled dual effect on synaptic strength and the lateral potentiation of synaptic efficacy. Finally, we discuss the potential implications of ECB signalling for astrocytes in brain pathology and animal behaviour.

Original languageEnglish (US)
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Issue number1654
StatePublished - Oct 19 2014

Bibliographical note

Publisher Copyright:
© 2014 The Author(s) Published by the Royal Society. All rights reserved.


  • Astrocytes
  • Communication
  • Endocannabinoids
  • Gliotransmitter release
  • Neuron glia
  • Tripartite synapses


Dive into the research topics of 'Astrocytes in endocannabinoid signalling'. Together they form a unique fingerprint.

Cite this