TY - JOUR
T1 - Astrocytes adjust the dynamic range of cortical network activity to control modality-specific sensory information processing
AU - Miguel-Quesada, Claudia
AU - Zaforas, Marta
AU - Herrera-Pérez, Salvador
AU - Lines, Justin
AU - Fernández-López, Elena
AU - Alonso-Calviño, Elena
AU - Ardaya, Maria
AU - Soria, Federico N.
AU - Araque, Alfonso
AU - Aguilar, Juan
AU - Rosa, Juliana M.
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2023/8/29
Y1 - 2023/8/29
N2 - Cortical neuron-astrocyte communication in response to peripheral sensory stimulation occurs in a topographic-, frequency-, and intensity-dependent manner. However, the contribution of this functional interaction to the processing of sensory inputs and consequent behavior remains unclear. We investigate the role of astrocytes in sensory information processing at circuit and behavioral levels by monitoring and manipulating astrocytic activity in vivo. We show that astrocytes control the dynamic range of the cortical network activity, optimizing its responsiveness to incoming sensory inputs. The astrocytic modulation of sensory processing contributes to setting the detection threshold for tactile and thermal behavior responses. The mechanism of such astrocytic control is mediated through modulation of inhibitory transmission to adjust the gain and sensitivity of responding networks. These results uncover a role for astrocytes in maintaining the cortical network activity in an optimal range to control behavior associated with specific sensory modalities.
AB - Cortical neuron-astrocyte communication in response to peripheral sensory stimulation occurs in a topographic-, frequency-, and intensity-dependent manner. However, the contribution of this functional interaction to the processing of sensory inputs and consequent behavior remains unclear. We investigate the role of astrocytes in sensory information processing at circuit and behavioral levels by monitoring and manipulating astrocytic activity in vivo. We show that astrocytes control the dynamic range of the cortical network activity, optimizing its responsiveness to incoming sensory inputs. The astrocytic modulation of sensory processing contributes to setting the detection threshold for tactile and thermal behavior responses. The mechanism of such astrocytic control is mediated through modulation of inhibitory transmission to adjust the gain and sensitivity of responding networks. These results uncover a role for astrocytes in maintaining the cortical network activity in an optimal range to control behavior associated with specific sensory modalities.
KW - astrocyte
KW - cortical network activity
KW - CP: Cell biology
KW - CP: Neuroscience
KW - dynamic range
KW - sensory information processing
KW - sensory specific modalities
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U2 - 10.1016/j.celrep.2023.112950
DO - 10.1016/j.celrep.2023.112950
M3 - Article
C2 - 37543946
AN - SCOPUS:85169504644
SN - 2211-1247
VL - 42
JO - Cell reports
JF - Cell reports
IS - 8
M1 - 112950
ER -