Astrocyte regulation of neural circuit activity and network states

João Filipe Oliveira, Alfonso Araque

Research output: Contribution to journalArticlepeer-review

Abstract

Astrocytes are known to influence neuronal activity through different mechanisms, including the homeostatic control of extracellular levels of ions and neurotransmitters and the exchange of signaling molecules that regulate synaptic formation, structure, and function. While a great effort done in the past has defined many molecular mechanisms and cellular processes involved in astrocyte-neuron interactions at the cellular level, the consequences of these interactions at the network level in vivo have only relatively recently been identified. This review describes and discusses recent findings on the regulatory effects of astrocytes on the activity of neuronal networks in vivo. Accumulating but still limited, evidence indicates that astrocytes regulate neuronal network rhythmic activity and synchronization as well as brain states. These studies demonstrate a critical contribution of astrocytes to brain activity and are paving the way for a more thorough understanding of the cellular bases of brain function.

Original languageEnglish (US)
Pages (from-to)1455-1466
Number of pages12
JournalGlia
Volume70
Issue number8
DOIs
StatePublished - Aug 2022

Bibliographical note

Funding Information:
This work was supported by grants from Foundation for Science and Technology IF/00328/2015, PTDC/MED‐NEU/31417/2017, UIDB/50026/2020 and UIDP/50026/2020; Bial Foundation (037/18); ”la Caixa” Foundation (LCF/PR/HR21/52410024) to J.F.O.; and National Institutes of Health‐MH (R01MH119355), National Institutes of Health‐NINDS (R01NS097312), National Institutes of Health‐NIDA (R01DA048822), and Department of Defense (W911NF2110328) to A.A. Funding information

Funding Information:
The authors are grateful to Drs. P. Kofuji, J. Aguilar and J. Lines for the critical reading of the manuscript. This work was supported by grants from Foundation for Science and Technology IF/00328/2015, PTDC/MED‐NEU/31417/2017, UIDB/50026/2020 and UIDP/50026/2020; Bial Foundation (037/18);”la Caixa” Foundation (LCF/PR/HR21/52410024) to J.F.O.; and National Institutes of Health‐MH (R01MH119355), National Institutes of Health‐NINDS (R01NS097312), National Institutes of Health‐NIDA (R01DA048822), and Department of Defense (W911NF2110328) to A.A.

Publisher Copyright:
© 2022 Wiley Periodicals LLC.

Keywords

  • astrocyte-neuron signaling
  • astrocytes
  • brain states
  • neural network activity
  • neuronal synchronization
  • tripartite synapses
  • Neurons/physiology
  • Astrocytes/physiology
  • Synapses/physiology
  • Brain/physiology
  • Synaptic Transmission/physiology

PubMed: MeSH publication types

  • Journal Article
  • Review

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