Astrocyte-neuron interaction at tripartite synapses

Alberto Pérez-Alvarez, Alfonso Araque

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Astrocytes, classically considered as supportive cells for neurons without a direct role in brain information processing, are emerging as relevant elements in brain physiology through their ability to regulate neuronal activity and synaptic transmission and plasticity. In relation to the key role of astrocyte-neuron interactions in synaptic physiology, accumulating evidence suggests that dysfunctions of neuron-astrocyte signaling may be linked to the pathology of various neurological and neurodegenerative diseases. In this article, we summarize the evidence supporting the importance of astrocyte-neuron communication in synaptic physiology, which have led to reveal astrocytes as integral elements of synaptic function. We also discuss how this novel view of astrocytic functions on brain physiology is prompting us to reconsider the possible astrocytic roles in brain diseases, and specifically in depression.

Original languageEnglish (US)
Pages (from-to)1220-1224
Number of pages5
JournalCurrent Drug Targets
Volume14
Issue number11
DOIs
StatePublished - Nov 25 2013

Keywords

  • Astrocytes
  • Glia
  • Gliotransmission
  • Glutamate
  • LTP
  • Synaptic transmission
  • Tripartite synapse

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