Astrocyte and neuron cooperation in long-term depression

Caitlin Durkee; Paulo Kofuji; Marta Navarrete; Alfonso Araque

doi:10.1016/j.tins.2021.07.004

Astrocyte and neuron cooperation in long-term depression

Caitlin Durkee, Paulo Kofuji, Marta Navarrete, Alfonso Araque

Neuroscience

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

Activity-dependent long-term changes in synaptic transmission known as synaptic plasticity are fundamental processes in brain function and are recognized as the cellular basis of learning and memory. While the neuronal mechanisms underlying synaptic plasticity have been largely identified, the involvement of astrocytes in these processes has been less recognized. However, astrocytes are emerging as important cells that regulate synaptic function by interacting with neurons at tripartite synapses. In this review, we discuss recent evidence suggesting that astrocytes are necessary elements in long-term synaptic depression (LTD). We highlight the mechanistic heterogeneity of astrocyte contribution to this form of synaptic plasticity and propose that astrocytes are integral participants in LTD.

Original language	English (US)
Pages (from-to)	837-848
Number of pages	12
Journal	Trends in Neurosciences
Volume	44
Issue number	10
DOIs	https://doi.org/10.1016/j.tins.2021.07.004
State	Published - Oct 2021

Bibliographical note

Funding Information:
The authors would like to thank María José Acuyo Ruiz for assistance with the figures. This work was supported by grants from the Spanish Ministry of Science and Innovation (Ramón y Cajal RYC-2016-20414 and RTI2018-094887-B-I00 ) and Fondo Europeo de Desarrollo Regional (FEDER) to M.N.; and National Institutes of Health-MH ( R01MH119355 ), National Institutes of Health-NINDS ( R01NS097312 ), and National Institutes of Health-NIDA ( R01DA048822 ) to A.A.

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

calcium signaling
gliotransmission
long-term depression
synaptic plasticity
tripartite synapses

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10.1016/j.tins.2021.07.004

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title = "Astrocyte and neuron cooperation in long-term depression",

abstract = "Activity-dependent long-term changes in synaptic transmission known as synaptic plasticity are fundamental processes in brain function and are recognized as the cellular basis of learning and memory. While the neuronal mechanisms underlying synaptic plasticity have been largely identified, the involvement of astrocytes in these processes has been less recognized. However, astrocytes are emerging as important cells that regulate synaptic function by interacting with neurons at tripartite synapses. In this review, we discuss recent evidence suggesting that astrocytes are necessary elements in long-term synaptic depression (LTD). We highlight the mechanistic heterogeneity of astrocyte contribution to this form of synaptic plasticity and propose that astrocytes are integral participants in LTD.",

keywords = "calcium signaling, gliotransmission, long-term depression, synaptic plasticity, tripartite synapses",

author = "Caitlin Durkee and Paulo Kofuji and Marta Navarrete and Alfonso Araque",

note = "Funding Information: The authors would like to thank Mar{\'i}a Jos{\'e} Acuyo Ruiz for assistance with the figures. This work was supported by grants from the Spanish Ministry of Science and Innovation (Ram{\'o}n y Cajal RYC-2016-20414 and RTI2018-094887-B-I00 ) and Fondo Europeo de Desarrollo Regional (FEDER) to M.N.; and National Institutes of Health-MH ( R01MH119355 ), National Institutes of Health-NINDS ( R01NS097312 ), and National Institutes of Health-NIDA ( R01DA048822 ) to A.A. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

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AU - Durkee, Caitlin

AU - Kofuji, Paulo

AU - Navarrete, Marta

AU - Araque, Alfonso

N1 - Funding Information: The authors would like to thank María José Acuyo Ruiz for assistance with the figures. This work was supported by grants from the Spanish Ministry of Science and Innovation (Ramón y Cajal RYC-2016-20414 and RTI2018-094887-B-I00 ) and Fondo Europeo de Desarrollo Regional (FEDER) to M.N.; and National Institutes of Health-MH ( R01MH119355 ), National Institutes of Health-NINDS ( R01NS097312 ), and National Institutes of Health-NIDA ( R01DA048822 ) to A.A. Publisher Copyright: © 2021 Elsevier Ltd

PY - 2021/10

Y1 - 2021/10

N2 - Activity-dependent long-term changes in synaptic transmission known as synaptic plasticity are fundamental processes in brain function and are recognized as the cellular basis of learning and memory. While the neuronal mechanisms underlying synaptic plasticity have been largely identified, the involvement of astrocytes in these processes has been less recognized. However, astrocytes are emerging as important cells that regulate synaptic function by interacting with neurons at tripartite synapses. In this review, we discuss recent evidence suggesting that astrocytes are necessary elements in long-term synaptic depression (LTD). We highlight the mechanistic heterogeneity of astrocyte contribution to this form of synaptic plasticity and propose that astrocytes are integral participants in LTD.

AB - Activity-dependent long-term changes in synaptic transmission known as synaptic plasticity are fundamental processes in brain function and are recognized as the cellular basis of learning and memory. While the neuronal mechanisms underlying synaptic plasticity have been largely identified, the involvement of astrocytes in these processes has been less recognized. However, astrocytes are emerging as important cells that regulate synaptic function by interacting with neurons at tripartite synapses. In this review, we discuss recent evidence suggesting that astrocytes are necessary elements in long-term synaptic depression (LTD). We highlight the mechanistic heterogeneity of astrocyte contribution to this form of synaptic plasticity and propose that astrocytes are integral participants in LTD.

KW - calcium signaling

KW - gliotransmission

KW - long-term depression

KW - synaptic plasticity

KW - tripartite synapses

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DO - 10.1016/j.tins.2021.07.004

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JO - Trends in Neurosciences

JF - Trends in Neurosciences

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Astrocyte and neuron cooperation in long-term depression

Abstract

Bibliographical note

Keywords

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