ASTCT, CIBMTR, and EBMT clinical practice recommendations for transplant and cellular therapies in mantle cell lymphoma

Pashna N. Munshi, Mehdi Hamadani, Ambuj Kumar, Peter Dreger, Jonathan W. Friedberg, Martin Dreyling, Brad Kahl, Mats Jerkeman, Mohamed A. Kharfan-Dabaja, Frederick L. Locke, Mazyar Shadman, Brian T. Hill, Sairah Ahmed, Alex F. Herrera, Craig S. Sauter, Veronika Bachanova, Nilanjan Ghosh, Matthew Lunning, Vaishalee P. Kenkre, Mahmoud AljurfMichael Wang, Kami J. Maddocks, John P. Leonard, Manali Kamdar, Tycel Phillips, Amanda F. Cashen, David J. Inwards, Anna Sureda, Jonathon B. Cohen, Sonali M. Smith, Carmello Carlo-Stella, Bipin Savani, Stephen P. Robinson, Timothy S. Fenske

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Autologous (auto-) or allogeneic (allo-) hematopoietic cell transplantation (HCT) are accepted treatment modalities for mantle cell lymphoma (MCL). Recently, chimeric antigen receptor (CAR) T-cell therapy received approval for MCL; however, its exact place and sequence in relation to HCT is unclear. The ASTCT, CIBMTR, and the EBMT, jointly convened an expert panel to formulate consensus recommendations for role, timing, and sequencing of auto-, allo-HCT, and CAR T-cell therapy for patients with newly diagnosed and relapsed/refractory (R/R) MCL. The RAND-modified Delphi method was used to generate consensus statements. Seventeen consensus statements were generated; in the first-line setting auto-HCT consolidation represents standard-of-care in eligible patients, whereas there is no clear role of allo-HCT or CAR T-cell therapy, outside of a clinical trial. In the R/R setting, the preferential option is CAR T-cell therapy especially in MCL failing or intolerant to at least one Bruton’s tyrosine kinase inhibitor, while allo-HCT is recommended if CAR T-cell therapy has failed or is not feasible. In the absence of contemporary evidence-based data, the panel found RAND-modified Delphi methodology effective in providing a formal framework for developing consensus recommendations for the timing and sequence of cellular therapies for MCL.

Original languageEnglish (US)
Pages (from-to)2911-2921
Number of pages11
JournalBone marrow transplantation
Volume56
Issue number12
Early online dateAug 20 2021
DOIs
StatePublished - Aug 20 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s).

Fingerprint

Dive into the research topics of 'ASTCT, CIBMTR, and EBMT clinical practice recommendations for transplant and cellular therapies in mantle cell lymphoma'. Together they form a unique fingerprint.

Cite this