Associations of weight loss and changes in fat distribution with the remission of hypertension in a bi-ethnic cohort: The Atherosclerosis Risk in Communities Study

[No Value] Juhaeri, June Stevens, L. E. Chambless, F. J. Nieto, Daniel Jones, Pamela Schreiner, Donna Arnett, Jianwen Cai

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background. To examine associations of weight loss and changes in fat distribution with changes in blood pressure and the remission of hypertension in a community-based sample. Methods. Participants were 3245 white and African-American men and women, 45-64 years of age, who participated in the Atherosclerosis Risk in Communities Study over an average of 9 years. Mixed models analyses were used to examine the associations of weight loss and changes in fat distribution with changes in blood pressure. Proportional hazard models with time-dependent covariates were used to examine the associations of weight loss and changes in fat distribution with the remission of hypertension. Results. Weight loss was associated with a decrease in systolic blood pressure and diastolic blood pressure and with an increased rate of remission of hypertension. Hazard ratios of the remission of hypertension associated with 1-kg increment in annual weight loss were 2.04 (95% confidence interval [CI]: 1.62-2.59), 1.38 (95% CI: 1.14-1.67), 1.84 (95% CI: 1.47-2.29), and 1.53 (95% CI: 1.14-2.05) for white women, African-American women, white men, and African-American men, respectively. Changes in fat distribution were associated with the remission of hypertension in younger (45-54 years) participants. Conclusions. Weight loss was associated with a decrease in blood pressure and with remission of hypertension in white and African-American men and women.

Original languageEnglish (US)
Pages (from-to)330-339
Number of pages10
JournalPreventive medicine
Volume36
Issue number3
DOIs
StatePublished - Mar 1 2003

Bibliographical note

Funding Information:
The ARIC study was funded by contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, and N01-HC-55022 from the U.S. National Heart, Lung, and Blood Institute. The authors thank the staff and participants in the ARIC study for their important contributions.

Keywords

  • African American
  • Fat distribution
  • Hypertension
  • Remission
  • Weight loss

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