Associations of the β-fibrinogen Hae III and factor XIII Val34Leu gene variants with venous thrombosis

Mary Cushman, Alexandra Cornell, Aaron R. Folsom, Lu Wang, Michael Y. Tsai, Joseph Polak, Zhonghua Tang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Introduction: The factor XIII Val34Leu (100 G → T) and β-fibrinogen Hae III (- 455 G → A) gene variants have been associated with reduced risk of venous thrombosis, but not in all studies. Methods: We investigated the associations of these polymorphisms with risk of venous thrombosis in a prospective, population-based study of 21,680 men and women aged 45-100 years at enrollment. Factor XIII 100 G/T and β-fibrinogen - 455 G/A were analyzed on stored DNA from 511 thrombosis cases and 1028 control subjects without thrombosis during follow up. Results: The β-fibrinogen A allele was present in 24.4% of cases and 32.3% of controls. Compared to GG subjects, the age, race, and sex adjusted odds ratio (OR) of venous thrombosis was 0.77 (95% CI 0.59-0.99) for GA subjects, and 0.60 (95% CI 0.31-1.16) for AA subjects. The adjusted OR of thrombosis associated with factor XIII 100 G/T was 1.01 (95% CI 0.81-1.26) for GT subjects and 0.45 (95% CI 0.44-1.19) for TT subjects, compared to GG. For both genotypes, ORs of thrombosis were similar in whites and non-whites, although there were no non-white fibrinogen AA cases. β-fibrinogen - 455 GA or AA attenuated the thrombosis risk associated with obesity (from 2.14 to 1.25) and factor V Leiden (from 3.89 to 2.36). Conclusions: β-fibrinogen - 455 G/A, but not factor XIII 100 G/T, was associated with a lower risk of venous thrombosis in this general population sample. β-fibrinogen - 455 A may attenuate the increased thrombosis risk associated with obesity or factor V Leiden.

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
JournalThrombosis Research
Volume121
Issue number3
DOIs
StatePublished - Dec 1 2007

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Factor XIII
Venous Thrombosis
Fibrinogen
Thrombosis
Genes
Obesity
Odds Ratio
Population
Alleles
Genotype
DNA

Keywords

  • Factor V Leiden
  • Factor XIII
  • Fibrinogen
  • Obesity
  • Risk factor
  • Venous thrombosis

Cite this

Associations of the β-fibrinogen Hae III and factor XIII Val34Leu gene variants with venous thrombosis. / Cushman, Mary; Cornell, Alexandra; Folsom, Aaron R.; Wang, Lu; Tsai, Michael Y.; Polak, Joseph; Tang, Zhonghua.

In: Thrombosis Research, Vol. 121, No. 3, 01.12.2007, p. 339-345.

Research output: Contribution to journalArticle

Cushman, Mary ; Cornell, Alexandra ; Folsom, Aaron R. ; Wang, Lu ; Tsai, Michael Y. ; Polak, Joseph ; Tang, Zhonghua. / Associations of the β-fibrinogen Hae III and factor XIII Val34Leu gene variants with venous thrombosis. In: Thrombosis Research. 2007 ; Vol. 121, No. 3. pp. 339-345.
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abstract = "Introduction: The factor XIII Val34Leu (100 G → T) and β-fibrinogen Hae III (- 455 G → A) gene variants have been associated with reduced risk of venous thrombosis, but not in all studies. Methods: We investigated the associations of these polymorphisms with risk of venous thrombosis in a prospective, population-based study of 21,680 men and women aged 45-100 years at enrollment. Factor XIII 100 G/T and β-fibrinogen - 455 G/A were analyzed on stored DNA from 511 thrombosis cases and 1028 control subjects without thrombosis during follow up. Results: The β-fibrinogen A allele was present in 24.4{\%} of cases and 32.3{\%} of controls. Compared to GG subjects, the age, race, and sex adjusted odds ratio (OR) of venous thrombosis was 0.77 (95{\%} CI 0.59-0.99) for GA subjects, and 0.60 (95{\%} CI 0.31-1.16) for AA subjects. The adjusted OR of thrombosis associated with factor XIII 100 G/T was 1.01 (95{\%} CI 0.81-1.26) for GT subjects and 0.45 (95{\%} CI 0.44-1.19) for TT subjects, compared to GG. For both genotypes, ORs of thrombosis were similar in whites and non-whites, although there were no non-white fibrinogen AA cases. β-fibrinogen - 455 GA or AA attenuated the thrombosis risk associated with obesity (from 2.14 to 1.25) and factor V Leiden (from 3.89 to 2.36). Conclusions: β-fibrinogen - 455 G/A, but not factor XIII 100 G/T, was associated with a lower risk of venous thrombosis in this general population sample. β-fibrinogen - 455 A may attenuate the increased thrombosis risk associated with obesity or factor V Leiden.",
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T1 - Associations of the β-fibrinogen Hae III and factor XIII Val34Leu gene variants with venous thrombosis

AU - Cushman, Mary

AU - Cornell, Alexandra

AU - Folsom, Aaron R.

AU - Wang, Lu

AU - Tsai, Michael Y.

AU - Polak, Joseph

AU - Tang, Zhonghua

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Introduction: The factor XIII Val34Leu (100 G → T) and β-fibrinogen Hae III (- 455 G → A) gene variants have been associated with reduced risk of venous thrombosis, but not in all studies. Methods: We investigated the associations of these polymorphisms with risk of venous thrombosis in a prospective, population-based study of 21,680 men and women aged 45-100 years at enrollment. Factor XIII 100 G/T and β-fibrinogen - 455 G/A were analyzed on stored DNA from 511 thrombosis cases and 1028 control subjects without thrombosis during follow up. Results: The β-fibrinogen A allele was present in 24.4% of cases and 32.3% of controls. Compared to GG subjects, the age, race, and sex adjusted odds ratio (OR) of venous thrombosis was 0.77 (95% CI 0.59-0.99) for GA subjects, and 0.60 (95% CI 0.31-1.16) for AA subjects. The adjusted OR of thrombosis associated with factor XIII 100 G/T was 1.01 (95% CI 0.81-1.26) for GT subjects and 0.45 (95% CI 0.44-1.19) for TT subjects, compared to GG. For both genotypes, ORs of thrombosis were similar in whites and non-whites, although there were no non-white fibrinogen AA cases. β-fibrinogen - 455 GA or AA attenuated the thrombosis risk associated with obesity (from 2.14 to 1.25) and factor V Leiden (from 3.89 to 2.36). Conclusions: β-fibrinogen - 455 G/A, but not factor XIII 100 G/T, was associated with a lower risk of venous thrombosis in this general population sample. β-fibrinogen - 455 A may attenuate the increased thrombosis risk associated with obesity or factor V Leiden.

AB - Introduction: The factor XIII Val34Leu (100 G → T) and β-fibrinogen Hae III (- 455 G → A) gene variants have been associated with reduced risk of venous thrombosis, but not in all studies. Methods: We investigated the associations of these polymorphisms with risk of venous thrombosis in a prospective, population-based study of 21,680 men and women aged 45-100 years at enrollment. Factor XIII 100 G/T and β-fibrinogen - 455 G/A were analyzed on stored DNA from 511 thrombosis cases and 1028 control subjects without thrombosis during follow up. Results: The β-fibrinogen A allele was present in 24.4% of cases and 32.3% of controls. Compared to GG subjects, the age, race, and sex adjusted odds ratio (OR) of venous thrombosis was 0.77 (95% CI 0.59-0.99) for GA subjects, and 0.60 (95% CI 0.31-1.16) for AA subjects. The adjusted OR of thrombosis associated with factor XIII 100 G/T was 1.01 (95% CI 0.81-1.26) for GT subjects and 0.45 (95% CI 0.44-1.19) for TT subjects, compared to GG. For both genotypes, ORs of thrombosis were similar in whites and non-whites, although there were no non-white fibrinogen AA cases. β-fibrinogen - 455 GA or AA attenuated the thrombosis risk associated with obesity (from 2.14 to 1.25) and factor V Leiden (from 3.89 to 2.36). Conclusions: β-fibrinogen - 455 G/A, but not factor XIII 100 G/T, was associated with a lower risk of venous thrombosis in this general population sample. β-fibrinogen - 455 A may attenuate the increased thrombosis risk associated with obesity or factor V Leiden.

KW - Factor V Leiden

KW - Factor XIII

KW - Fibrinogen

KW - Obesity

KW - Risk factor

KW - Venous thrombosis

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