TY - JOUR
T1 - Associations of plasma phospholipid omega-6 and omega-3 polyunsaturated fatty acid levels and MRI measures of cardiovascular structure and function
T2 - The multiethnic study of atherosclerosis
AU - Anderson, Jennifer S.
AU - Nettleton, Jennifer A.
AU - Hundley, W. Gregory
AU - Tsai, Michael Y.
AU - Steffen, Lyn M.
AU - Lemaitre, Rozenn N.
AU - Siscovick, David
AU - Lima, João
AU - Prince, Martin R.
AU - Herrington, David
PY - 2011
Y1 - 2011
N2 - Background. The association between plasma omega-6 fatty acids and cardiovascular disease (CVD) is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid. Methods. Associations of plasma phospholipid fatty acid levels (arachidonic acid, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid (DHA), and alpha-linolenic acid) with cardiac magnetic resonance imaging measures of left ventricular (LV) mass, LV volume, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults. Results. Results of multivariate analysis showed no statistically significant associations of plasma omega-6 or omega-3 levels with cardiac magnetic resonance imaging measures. Stratification by gender revealed a positive association between DHA and LV mass in women (β = 1.89, P = 0.02; P interaction = 0.003) and a trend for a positive association between DHA and ejection fraction in men (β = 0.009, P = 0.05; P interaction = 0.03). Conclusion. Additional research is warranted to clarify the effects of plasma DHA on cardiac structure and function in women versus men.
AB - Background. The association between plasma omega-6 fatty acids and cardiovascular disease (CVD) is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid. Methods. Associations of plasma phospholipid fatty acid levels (arachidonic acid, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid (DHA), and alpha-linolenic acid) with cardiac magnetic resonance imaging measures of left ventricular (LV) mass, LV volume, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults. Results. Results of multivariate analysis showed no statistically significant associations of plasma omega-6 or omega-3 levels with cardiac magnetic resonance imaging measures. Stratification by gender revealed a positive association between DHA and LV mass in women (β = 1.89, P = 0.02; P interaction = 0.003) and a trend for a positive association between DHA and ejection fraction in men (β = 0.009, P = 0.05; P interaction = 0.03). Conclusion. Additional research is warranted to clarify the effects of plasma DHA on cardiac structure and function in women versus men.
UR - http://www.scopus.com/inward/record.url?scp=84873157303&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873157303&partnerID=8YFLogxK
U2 - 10.1155/2011/315134
DO - 10.1155/2011/315134
M3 - Article
C2 - 21869927
AN - SCOPUS:84873157303
SN - 2090-0724
VL - 2011
JO - Journal of Nutrition and Metabolism
JF - Journal of Nutrition and Metabolism
M1 - 315134
ER -
