Associations of objectively and subjectively measured sleep quality with subsequent cognitive decline in older community-dwelling men: The MrOS sleep study

Terri Blackwell, Kristine Yaffe, Alison Laffan, Sonia Ancoli-Israel, Susan Redline, Kristine E. Ensrud, Yeonsu Song, Katie L. Stone

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

Study Objectives: To examine associations of objectively and subjectively measured sleep with subsequent cognitive decline. Design: A population-based longitudinal study. Setting: Six centers in the United States. Participants: Participants were 2,822 cognitively intact community-dwelling older men (mean age 76.0 ± 5.3 y) followed over 3.4 ± 0.5 y. Interventions: None. Measurements and Results: Objectively measured sleep predictors from wrist actigraphy: total sleep time (TST), sleep efficiency (SE), wake after sleep onset (WASO), number of long wake episodes (LWEP). Self-reported sleep predictors: sleep quality (Pittsburgh Sleep Quality Index [PSQI]), daytime sleepiness (Epworth Sleepiness Scale [ESS]), TST. Clinically significant cognitive decline: five-point decline on the Modified Mini-Mental State examination (3MS), change score for the Trails B test time in the worse decile. Associations of sleep predictors and cognitive decline were examined with logistic regression and linear mixed models. After multivariable adjustment, higher levels of WASO and LWEP and lower SE were associated with an 1.4 to 1.5-fold increase in odds of clinically significant decline (odds ratio 95% confidence interval) Trails B test: SE < 70% versus SE ≥ 70%: 1.53 (1.07, 2.18); WASO ≥ 90 min versus WASO < 90 min: 1.47 (1.09, 1.98); eight or more LWEP versus fewer than eight: 1.38 (1.02, 1.86). 3MS: eight or more LWEP versus fewer than eight: 1.36 (1.09, 1.71), with modest relationships to linear change in cognition over time. PSQI was related to decline in Trails B performance (3 sec/y per standard deviation increase). Conclusions: Among older community-dwelling men, reduced sleep efficiency, greater nighttime wakefulness, greater number of long wake episodes, and poor self-reported sleep quality were associated with subsequent cognitive decline.

Original languageEnglish (US)
Pages (from-to)655-663
Number of pages9
JournalSleep
Volume37
Issue number4
DOIs
StatePublished - Apr 1 2014

Keywords

  • Aging
  • Cognitive function
  • Disturbed sleep
  • Total sleep time

Fingerprint

Dive into the research topics of 'Associations of objectively and subjectively measured sleep quality with subsequent cognitive decline in older community-dwelling men: The MrOS sleep study'. Together they form a unique fingerprint.

Cite this