Objective: We reported association of haplotypes formed by IL-1b (IL1B)-511C/T (rs16944) and a variable number of tandem repeats (rs2234663) in intron 3 of IL-1 receptor antagonist (IL1RN) with rate of lung function decline in smoking-induced COPD. The aim of current study was to further investigate this association. Methods: We genotyped an additional 19 polymorphisms in IL1 cluster (including IL1A, IL1B and IL1RN) in non-Hispanic whites who had the fastest (n = 268) and the slowest (n = 292) decline of FEV1% predicted in the same study. We also analyzed the association of all 21 polymorphisms with serum CRP levels. Results: None of 21 polymorphisms showed significant association with rate of decline of lung function or CRP levels after adjusting for multiple comparisons. Before adjusting for multiple comparisons, only IL1RN_19327 (rs315949) showed significant association with lung function decline (P = 0.03, additive model). The frequencies of genotypes containing the IL1RN_19327A allele were 71.9% and 62.2%, respectively in the fast and slow decline groups (P = 0.02, odds ratio = 1.6, 95% confidence interval = 1.1-2.3); the IL1B_5200 (rs1143633) and rs2234663 in IL1RN were associated with serum CRP levels (P=0.04 and 0.03, respectively). Conclusions: No single marker was significantly associated with either rate of lung function decline or serum CRP levels.
|Original language||English (US)|
|Number of pages||11|
|Journal||International Journal of Clinical and Experimental Pathology|
|State||Published - 2015|
Bibliographical noteFunding Information:
The authors are grateful to all the subjects who have contributed to the study in the Lung Health Study. This study was supported by grants from National Natural Science Foundation of China (grants No. 81170042/H0108), the British Columbia Lung Association, the Canadian Institutes of Health Research and National Institutes of Health Grant 5R01HL064068-04.
- C-reactive protein
- Chronic obstructive pulmonary disease (COPD)
- Forced expiratory volume in one second (FEV)
- Genetic polymorphism
- IL1 gene cluster
- Lung function decline