Abstract
Concentration of 25-hydroxyvitamin D3 (25(OH)D3), the main circulating form of vitamin D, is inversely associated with incident, sporadic colorectal adenoma risk. We investigated whether this association differs by 2 functional variants in the vitamin D-binding protein (DBP) gene, group-specific component (GC), that encode for common protein isoforms Gc1s, Gc1f, and Gc2 linked to differences in vitamin D metabolism. We pooled data (418 patients with adenoma and 524 polyp-free control subjects) from 3 colonoscopy-based case-control studies (Minnesota, 1991-1994; North Carolina, 1994-1997; South Carolina, 2002). We estimated 25(OH)D3-adenoma associations, stratified by DBP isoforms, using multivariable logistic regression. Higher 25(OH)D3 concentrations were inversely associated with colorectal adenoma risk among those with the Gc2 isoform (per 10-ng/mL increase in 25(OH)D3, odds ratio = 0.71, 95% confidence interval: 0.56, 0.90), but not among those with only Gc1 isoforms (odds ratio = 1.07, 95% confidence interval: 0.87, 1.32; P for interaction = 0.03). Thus, the vitamin D-incident, sporadic colorectal adenoma association may differ by common DBP isoforms, and patients with the Gc2 isoform may particularly benefit from maintaining higher circulating 25(OH)D3 concentrations for adenoma prevention.
Original language | English (US) |
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Pages (from-to) | 1923-1930 |
Number of pages | 8 |
Journal | American journal of epidemiology |
Volume | 187 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2018 |
Bibliographical note
Funding Information:This research was funded by National Institutes of Health (grants P01 CA50305, R01 CA66539, and R01 CA116795); Fullerton Foundation; Emory Winship Cancer Institute; a Georgia Cancer Coalition Distinguished Scholar award (to R.M.B.); and Franklin Foundation. Conflict of interest: none declared.
Publisher Copyright:
© 2018 The Author(s).
Keywords
- Case-control studies
- Colorectal neoplasms
- Gene-environment interaction
- Vitamin D
- Vitamin D-binding protein