Associations of Binge Drinking With Vascular Brain Injury and Atrophy in Older American Indians: The Strong Heart Study

Jordan P. Lewis; Astrid M. Suchy-Dicey; Carolyn Noonan; Valarie Blue Bird Jernigan; Jason G. Umans; Kimiko Domoto-Reilly; Dedra S. Buchwald; Spero M. Manson

doi:10.1177/08982643211013696

Associations of Binge Drinking With Vascular Brain Injury and Atrophy in Older American Indians: The Strong Heart Study

Jordan P. Lewis, Astrid M. Suchy-Dicey, Carolyn Noonan, Valarie Blue Bird Jernigan, Jason G. Umans, Kimiko Domoto-Reilly, Dedra S. Buchwald, Spero M. Manson

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: American Indians (AIs) generally consume less alcohol than the US general population; however, the prevalence of alcohol use disorder is higher. This is the first large cohort study to examine binge drinking as a risk factor for vascular brain injury (VBI). Methods: We used linear and Poisson regression to examine the association of self-reported binge drinking with VBI, measured via magnetic resonance imaging (MRI), in 817 older AIs who participated in the Strong Heart and Cerebrovascular Disease and Its Consequences in American Indians studies. Results: Any binge drinking at multiple time-points was associated with increased sulcal (β = 0.360, 95% CI [0.079, 0.641]) and ventricle dilatation (β = 0.512, 95% CI [0.174, 0.850]) compared to no binge drinking. Discussion: These observed associations are consistent with previous findings. Identifying how binge drinking may contribute to VBI in older AIs may suggest modifiable health behaviors for neurological risk reduction and disease prevention.

Original language	English (US)
Pages (from-to)	51S-59S
Journal	Journal of aging and health
Volume	33
Issue number	7-8_suppl
DOIs	https://doi.org/10.1177/08982643211013696
State	Published - Jun 26 2021
Externally published	Yes

Bibliographical note

Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by funding from the National Heart Lung and Blood Institute [U01HL41642, U01HL41652, U01HL41654, U01HL65520, U01HL65521, R01HL109315, R01HL109301, R01HL109284, R01HL109282, R01HL109319, R01HL093086, P60MD000507, P30AG15297] and the University of Washington Alzheimer’s Disease Research Center [P50AG005136]. The opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the National Institutes of Health (NIH).

Funding Information:
We wish to thank all study participants, field sites, and staff. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by funding from the National Heart Lung and Blood Institute [U01HL41642, U01HL41652, U01HL41654, U01HL65520, U01HL65521, R01HL109315, R01HL109301, R01HL109284, R01HL109282, R01HL109319, R01HL093086, P60MD000507, P30AG15297] and the University of Washington Alzheimer?s Disease Research Center [P50AG005136]. The opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the National Institutes of Health (NIH).

Publisher Copyright:
© The Author(s) 2021.

Keywords

American Indian
binge drinking
older adults

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{76a3483184dd4f48adbef8ae816294a7,

title = "Associations of Binge Drinking With Vascular Brain Injury and Atrophy in Older American Indians: The Strong Heart Study",

abstract = "Objectives: American Indians (AIs) generally consume less alcohol than the US general population; however, the prevalence of alcohol use disorder is higher. This is the first large cohort study to examine binge drinking as a risk factor for vascular brain injury (VBI). Methods: We used linear and Poisson regression to examine the association of self-reported binge drinking with VBI, measured via magnetic resonance imaging (MRI), in 817 older AIs who participated in the Strong Heart and Cerebrovascular Disease and Its Consequences in American Indians studies. Results: Any binge drinking at multiple time-points was associated with increased sulcal (β = 0.360, 95% CI [0.079, 0.641]) and ventricle dilatation (β = 0.512, 95% CI [0.174, 0.850]) compared to no binge drinking. Discussion: These observed associations are consistent with previous findings. Identifying how binge drinking may contribute to VBI in older AIs may suggest modifiable health behaviors for neurological risk reduction and disease prevention.",

keywords = "American Indian, binge drinking, older adults",

author = "Lewis, {Jordan P.} and Suchy-Dicey, {Astrid M.} and Carolyn Noonan and {Blue Bird Jernigan}, Valarie and Umans, {Jason G.} and Kimiko Domoto-Reilly and Buchwald, {Dedra S.} and Manson, {Spero M.}",

note = "Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by funding from the National Heart Lung and Blood Institute [U01HL41642, U01HL41652, U01HL41654, U01HL65520, U01HL65521, R01HL109315, R01HL109301, R01HL109284, R01HL109282, R01HL109319, R01HL093086, P60MD000507, P30AG15297] and the University of Washington Alzheimer{\textquoteright}s Disease Research Center [P50AG005136]. The opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the National Institutes of Health (NIH). Funding Information: We wish to thank all study participants, field sites, and staff. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by funding from the National Heart Lung and Blood Institute [U01HL41642, U01HL41652, U01HL41654, U01HL65520, U01HL65521, R01HL109315, R01HL109301, R01HL109284, R01HL109282, R01HL109319, R01HL093086, P60MD000507, P30AG15297] and the University of Washington Alzheimer?s Disease Research Center [P50AG005136]. The opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the National Institutes of Health (NIH). Publisher Copyright: {\textcopyright} The Author(s) 2021.",

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month = jun,

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doi = "10.1177/08982643211013696",

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AU - Lewis, Jordan P.

AU - Suchy-Dicey, Astrid M.

AU - Noonan, Carolyn

AU - Blue Bird Jernigan, Valarie

AU - Umans, Jason G.

AU - Domoto-Reilly, Kimiko

AU - Buchwald, Dedra S.

AU - Manson, Spero M.

N1 - Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by funding from the National Heart Lung and Blood Institute [U01HL41642, U01HL41652, U01HL41654, U01HL65520, U01HL65521, R01HL109315, R01HL109301, R01HL109284, R01HL109282, R01HL109319, R01HL093086, P60MD000507, P30AG15297] and the University of Washington Alzheimer’s Disease Research Center [P50AG005136]. The opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the National Institutes of Health (NIH). Funding Information: We wish to thank all study participants, field sites, and staff. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by funding from the National Heart Lung and Blood Institute [U01HL41642, U01HL41652, U01HL41654, U01HL65520, U01HL65521, R01HL109315, R01HL109301, R01HL109284, R01HL109282, R01HL109319, R01HL093086, P60MD000507, P30AG15297] and the University of Washington Alzheimer?s Disease Research Center [P50AG005136]. The opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the National Institutes of Health (NIH). Publisher Copyright: © The Author(s) 2021.

PY - 2021/6/26

Y1 - 2021/6/26

N2 - Objectives: American Indians (AIs) generally consume less alcohol than the US general population; however, the prevalence of alcohol use disorder is higher. This is the first large cohort study to examine binge drinking as a risk factor for vascular brain injury (VBI). Methods: We used linear and Poisson regression to examine the association of self-reported binge drinking with VBI, measured via magnetic resonance imaging (MRI), in 817 older AIs who participated in the Strong Heart and Cerebrovascular Disease and Its Consequences in American Indians studies. Results: Any binge drinking at multiple time-points was associated with increased sulcal (β = 0.360, 95% CI [0.079, 0.641]) and ventricle dilatation (β = 0.512, 95% CI [0.174, 0.850]) compared to no binge drinking. Discussion: These observed associations are consistent with previous findings. Identifying how binge drinking may contribute to VBI in older AIs may suggest modifiable health behaviors for neurological risk reduction and disease prevention.

AB - Objectives: American Indians (AIs) generally consume less alcohol than the US general population; however, the prevalence of alcohol use disorder is higher. This is the first large cohort study to examine binge drinking as a risk factor for vascular brain injury (VBI). Methods: We used linear and Poisson regression to examine the association of self-reported binge drinking with VBI, measured via magnetic resonance imaging (MRI), in 817 older AIs who participated in the Strong Heart and Cerebrovascular Disease and Its Consequences in American Indians studies. Results: Any binge drinking at multiple time-points was associated with increased sulcal (β = 0.360, 95% CI [0.079, 0.641]) and ventricle dilatation (β = 0.512, 95% CI [0.174, 0.850]) compared to no binge drinking. Discussion: These observed associations are consistent with previous findings. Identifying how binge drinking may contribute to VBI in older AIs may suggest modifiable health behaviors for neurological risk reduction and disease prevention.

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KW - older adults

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ER -

Associations of Binge Drinking With Vascular Brain Injury and Atrophy in Older American Indians: The Strong Heart Study

Abstract

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Keywords

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