Associations of Binge Drinking With Vascular Brain Injury and Atrophy in Older American Indians: The Strong Heart Study

Jordan P. Lewis, Astrid M. Suchy-Dicey, Carolyn Noonan, Valarie Blue Bird Jernigan, Jason G. Umans, Kimiko Domoto-Reilly, Dedra S. Buchwald, Spero M. Manson

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: American Indians (AIs) generally consume less alcohol than the US general population; however, the prevalence of alcohol use disorder is higher. This is the first large cohort study to examine binge drinking as a risk factor for vascular brain injury (VBI). Methods: We used linear and Poisson regression to examine the association of self-reported binge drinking with VBI, measured via magnetic resonance imaging (MRI), in 817 older AIs who participated in the Strong Heart and Cerebrovascular Disease and Its Consequences in American Indians studies. Results: Any binge drinking at multiple time-points was associated with increased sulcal (β = 0.360, 95% CI [0.079, 0.641]) and ventricle dilatation (β = 0.512, 95% CI [0.174, 0.850]) compared to no binge drinking. Discussion: These observed associations are consistent with previous findings. Identifying how binge drinking may contribute to VBI in older AIs may suggest modifiable health behaviors for neurological risk reduction and disease prevention.

Original languageEnglish (US)
Pages (from-to)51S-59S
JournalJournal of aging and health
Volume33
Issue number7-8_suppl
DOIs
StatePublished - Jun 26 2021
Externally publishedYes

Bibliographical note

Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by funding from the National Heart Lung and Blood Institute [U01HL41642, U01HL41652, U01HL41654, U01HL65520, U01HL65521, R01HL109315, R01HL109301, R01HL109284, R01HL109282, R01HL109319, R01HL093086, P60MD000507, P30AG15297] and the University of Washington Alzheimer’s Disease Research Center [P50AG005136]. The opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the National Institutes of Health (NIH).

Funding Information:
We wish to thank all study participants, field sites, and staff. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by funding from the National Heart Lung and Blood Institute [U01HL41642, U01HL41652, U01HL41654, U01HL65520, U01HL65521, R01HL109315, R01HL109301, R01HL109284, R01HL109282, R01HL109319, R01HL093086, P60MD000507, P30AG15297] and the University of Washington Alzheimer?s Disease Research Center [P50AG005136]. The opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the National Institutes of Health (NIH).

Publisher Copyright:
© The Author(s) 2021.

Keywords

  • American Indian
  • binge drinking
  • older adults

PubMed: MeSH publication types

  • Journal Article

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