Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors: The CARDIA study

Kara M. Whitaker; Kelley Pettee Gabriel; Matthew P. Buman; Mark A. Pereira; David R. Jacobs; Jared P. Reis; Bethany Barone Gibbs; Mercedes R. Carnethon; John Staudenmayer; Stephen Sidney; Barbara Sternfeld

doi:10.1161/JAHA.118.010212

Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors: The CARDIA study

Kara M. Whitaker, Kelley Pettee Gabriel, Matthew P. Buman, Mark A. Pereira, David R. Jacobs, Jared P. Reis, Bethany Barone Gibbs, Mercedes R. Carnethon, John Staudenmayer, Stephen Sidney, Barbara Sternfeld

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Background Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity; however, existing studies are limited by cross-sectional study designs. Methods and Results Participants were 1922 adults from the CARDIA (Coronary Artery Risk Development in Young Adults) study. Linear regression examined the associations of sedentary, light-intensity physical activity, and moderate-to-vigorous intensity physical activity at year 20 (2005-2006) with waist circumference, blood pressure, glucose, insulin, triglycerides, high-density lipoprotein cholesterol, and a composite risk score at year 30 (2015-2016). Models then examined change in activity with change in cardiometabolic risk over the same 10-year period. Replacing 30 min/day of sedentary time with 30 min/day of light-intensity physical activity at year 20 was associated with a lower composite risk score (-0.01 SD [95% CI, -0.02, -0.00]) at year 30, characterized by lower waist circumference (0.15 cm [95% CI, -0.27, 0.02]), insulin (0.20 μU/mL [95% CI, -0.35, -0.04]), and higher high-density lipoprotein cholesterol (0.20 mg/dL [95% CI, 0.00, 0.40]; all P<0.05). An increase of 30 min/day in MVPA from year 20 to year 30, when replacing an equivalent increase in sedentary time, was associated with a decrease in the composite risk score (-0.08 [95% CI, -0.13, -0.04]) over the same 10 years, characterized by a decrease in waist circumference (1.52 cm [95% CI, -2.21, -0.84]), insulin (-1.13 μU/mL [95% CI, -1.95, -0.31]), triglycerides (-6.92 mg/dL [95% CI, -11.69, -2.15]), and an increase in high-density lipoprotein cholesterol (1.59 mg/dL [95% CI, 0.45, 2.73]; all P<0.05). Conclusions Replacement of sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity is associated with improved cardiometabolic health 10 years later.

Original language	English (US)
Article number	e010212
Journal	Journal of the American Heart Association
Volume	8
Issue number	1
DOIs	https://doi.org/10.1161/JAHA.118.010212
State	Published - Jan 8 2019

Bibliographical note

Funding Information:
The Coronary Artery Risk Development in Young Adults Study (CARDIA) is supported by contracts HHSN268201300025C, HHSN268201300026C, HHSN268201300027C, HHSN2682 01300028C, HHSN268201300029C, and HHSN26820090 0041C from the National Heart, Lung, and Blood Institute (NHLBI), the Intramural Research Program of the National Institute on Aging (NIA), and an intra-agency agreement between the NIA and NHLBI (AG0005). Accelerometer data collection was supported by grants R01 HL078972 and R56 HL125423 from the NHLBI. Whitaker was supported by T32 HL007779 from the NHLBI.

Funding Information:
The Coronary Artery Risk Development in Young Adults Study (CARDIA) is supported by contracts HHSN268201300025C, HHSN268201300026C, HHSN268201300027C, HHSN268201300028C, HHSN268201300029C, and HHSN26820090 0041C from the National Heart, Lung, and Blood Institute (NHLBI), the Intramural Research Program of the National Institute on Aging (NIA), and an intra-agency agreement between the NIA and NHLBI (AG0005). Accelerometer data collection was supported by grants R01 HL078972 and R56 HL125423 from the NHLBI. Whitaker was supported by T32 HL007779 from the NHLBI.

Publisher Copyright:
© 2019 The Authors.

Keywords

Cardiometabolic risk
Epidemiology
Isotemporal substitution
Physical activity
Sedentary time
Accelerometry/methods
Blood Pressure/physiology
Prospective Studies
Cross-Sectional Studies
Follow-Up Studies
Humans
Risk Factors
Exercise/physiology
Male
Incidence
Young Adult
United States/epidemiology
Time Factors
Adolescent
Adult
Female
Cardiovascular Diseases/diagnosis
Sedentary Behavior

PubMed: MeSH publication types

Multicenter Study
Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1161/JAHA.118.010212

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405708

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Whitaker, K. M., Gabriel, K. P., Buman, M. P., Pereira, M. A., Jacobs, D. R., Reis, J. P., Gibbs, B. B., Carnethon, M. R., Staudenmayer, J., Sidney, S., & Sternfeld, B. (2019). Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors: The CARDIA study. Journal of the American Heart Association, 8(1), [e010212]. https://doi.org/10.1161/JAHA.118.010212

Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors: The CARDIA study. / Whitaker, Kara M.; Gabriel, Kelley Pettee; Buman, Matthew P. et al.
In: Journal of the American Heart Association, Vol. 8, No. 1, e010212, 08.01.2019.

Research output: Contribution to journal › Article › peer-review

Whitaker, KM, Gabriel, KP, Buman, MP, Pereira, MA , Jacobs, DR, Reis, JP, Gibbs, BB, Carnethon, MR, Staudenmayer, J, Sidney, S & Sternfeld, B 2019, 'Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors: The CARDIA study', Journal of the American Heart Association, vol. 8, no. 1, e010212. https://doi.org/10.1161/JAHA.118.010212

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title = "Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors: The CARDIA study",

abstract = "Background Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity; however, existing studies are limited by cross-sectional study designs. Methods and Results Participants were 1922 adults from the CARDIA (Coronary Artery Risk Development in Young Adults) study. Linear regression examined the associations of sedentary, light-intensity physical activity, and moderate-to-vigorous intensity physical activity at year 20 (2005-2006) with waist circumference, blood pressure, glucose, insulin, triglycerides, high-density lipoprotein cholesterol, and a composite risk score at year 30 (2015-2016). Models then examined change in activity with change in cardiometabolic risk over the same 10-year period. Replacing 30 min/day of sedentary time with 30 min/day of light-intensity physical activity at year 20 was associated with a lower composite risk score (-0.01 SD [95% CI, -0.02, -0.00]) at year 30, characterized by lower waist circumference (0.15 cm [95% CI, -0.27, 0.02]), insulin (0.20 μU/mL [95% CI, -0.35, -0.04]), and higher high-density lipoprotein cholesterol (0.20 mg/dL [95% CI, 0.00, 0.40]; all P<0.05). An increase of 30 min/day in MVPA from year 20 to year 30, when replacing an equivalent increase in sedentary time, was associated with a decrease in the composite risk score (-0.08 [95% CI, -0.13, -0.04]) over the same 10 years, characterized by a decrease in waist circumference (1.52 cm [95% CI, -2.21, -0.84]), insulin (-1.13 μU/mL [95% CI, -1.95, -0.31]), triglycerides (-6.92 mg/dL [95% CI, -11.69, -2.15]), and an increase in high-density lipoprotein cholesterol (1.59 mg/dL [95% CI, 0.45, 2.73]; all P<0.05). Conclusions Replacement of sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity is associated with improved cardiometabolic health 10 years later.",

keywords = "Cardiometabolic risk, Epidemiology, Isotemporal substitution, Physical activity, Sedentary time, Accelerometry/methods, Blood Pressure/physiology, Prospective Studies, Cross-Sectional Studies, Follow-Up Studies, Humans, Risk Factors, Exercise/physiology, Male, Incidence, Young Adult, United States/epidemiology, Time Factors, Adolescent, Adult, Female, Cardiovascular Diseases/diagnosis, Sedentary Behavior",

author = "Whitaker, {Kara M.} and Gabriel, {Kelley Pettee} and Buman, {Matthew P.} and Pereira, {Mark A.} and Jacobs, {David R.} and Reis, {Jared P.} and Gibbs, {Bethany Barone} and Carnethon, {Mercedes R.} and John Staudenmayer and Stephen Sidney and Barbara Sternfeld",

note = "Funding Information: The Coronary Artery Risk Development in Young Adults Study (CARDIA) is supported by contracts HHSN268201300025C, HHSN268201300026C, HHSN268201300027C, HHSN2682 01300028C, HHSN268201300029C, and HHSN26820090 0041C from the National Heart, Lung, and Blood Institute (NHLBI), the Intramural Research Program of the National Institute on Aging (NIA), and an intra-agency agreement between the NIA and NHLBI (AG0005). Accelerometer data collection was supported by grants R01 HL078972 and R56 HL125423 from the NHLBI. Whitaker was supported by T32 HL007779 from the NHLBI. Funding Information: The Coronary Artery Risk Development in Young Adults Study (CARDIA) is supported by contracts HHSN268201300025C, HHSN268201300026C, HHSN268201300027C, HHSN268201300028C, HHSN268201300029C, and HHSN26820090 0041C from the National Heart, Lung, and Blood Institute (NHLBI), the Intramural Research Program of the National Institute on Aging (NIA), and an intra-agency agreement between the NIA and NHLBI (AG0005). Accelerometer data collection was supported by grants R01 HL078972 and R56 HL125423 from the NHLBI. Whitaker was supported by T32 HL007779 from the NHLBI. Publisher Copyright: {\textcopyright} 2019 The Authors.",

year = "2019",

month = jan,

day = "8",

doi = "10.1161/JAHA.118.010212",

language = "English (US)",

volume = "8",

journal = "Journal of the American Heart Association",

issn = "2047-9980",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors

T2 - The CARDIA study

AU - Whitaker, Kara M.

AU - Gabriel, Kelley Pettee

AU - Buman, Matthew P.

AU - Pereira, Mark A.

AU - Jacobs, David R.

AU - Reis, Jared P.

AU - Gibbs, Bethany Barone

AU - Carnethon, Mercedes R.

AU - Staudenmayer, John

AU - Sidney, Stephen

AU - Sternfeld, Barbara

N1 - Funding Information: The Coronary Artery Risk Development in Young Adults Study (CARDIA) is supported by contracts HHSN268201300025C, HHSN268201300026C, HHSN268201300027C, HHSN2682 01300028C, HHSN268201300029C, and HHSN26820090 0041C from the National Heart, Lung, and Blood Institute (NHLBI), the Intramural Research Program of the National Institute on Aging (NIA), and an intra-agency agreement between the NIA and NHLBI (AG0005). Accelerometer data collection was supported by grants R01 HL078972 and R56 HL125423 from the NHLBI. Whitaker was supported by T32 HL007779 from the NHLBI. Funding Information: The Coronary Artery Risk Development in Young Adults Study (CARDIA) is supported by contracts HHSN268201300025C, HHSN268201300026C, HHSN268201300027C, HHSN268201300028C, HHSN268201300029C, and HHSN26820090 0041C from the National Heart, Lung, and Blood Institute (NHLBI), the Intramural Research Program of the National Institute on Aging (NIA), and an intra-agency agreement between the NIA and NHLBI (AG0005). Accelerometer data collection was supported by grants R01 HL078972 and R56 HL125423 from the NHLBI. Whitaker was supported by T32 HL007779 from the NHLBI. Publisher Copyright: © 2019 The Authors.

PY - 2019/1/8

Y1 - 2019/1/8

N2 - Background Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity; however, existing studies are limited by cross-sectional study designs. Methods and Results Participants were 1922 adults from the CARDIA (Coronary Artery Risk Development in Young Adults) study. Linear regression examined the associations of sedentary, light-intensity physical activity, and moderate-to-vigorous intensity physical activity at year 20 (2005-2006) with waist circumference, blood pressure, glucose, insulin, triglycerides, high-density lipoprotein cholesterol, and a composite risk score at year 30 (2015-2016). Models then examined change in activity with change in cardiometabolic risk over the same 10-year period. Replacing 30 min/day of sedentary time with 30 min/day of light-intensity physical activity at year 20 was associated with a lower composite risk score (-0.01 SD [95% CI, -0.02, -0.00]) at year 30, characterized by lower waist circumference (0.15 cm [95% CI, -0.27, 0.02]), insulin (0.20 μU/mL [95% CI, -0.35, -0.04]), and higher high-density lipoprotein cholesterol (0.20 mg/dL [95% CI, 0.00, 0.40]; all P<0.05). An increase of 30 min/day in MVPA from year 20 to year 30, when replacing an equivalent increase in sedentary time, was associated with a decrease in the composite risk score (-0.08 [95% CI, -0.13, -0.04]) over the same 10 years, characterized by a decrease in waist circumference (1.52 cm [95% CI, -2.21, -0.84]), insulin (-1.13 μU/mL [95% CI, -1.95, -0.31]), triglycerides (-6.92 mg/dL [95% CI, -11.69, -2.15]), and an increase in high-density lipoprotein cholesterol (1.59 mg/dL [95% CI, 0.45, 2.73]; all P<0.05). Conclusions Replacement of sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity is associated with improved cardiometabolic health 10 years later.

AB - Background Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity; however, existing studies are limited by cross-sectional study designs. Methods and Results Participants were 1922 adults from the CARDIA (Coronary Artery Risk Development in Young Adults) study. Linear regression examined the associations of sedentary, light-intensity physical activity, and moderate-to-vigorous intensity physical activity at year 20 (2005-2006) with waist circumference, blood pressure, glucose, insulin, triglycerides, high-density lipoprotein cholesterol, and a composite risk score at year 30 (2015-2016). Models then examined change in activity with change in cardiometabolic risk over the same 10-year period. Replacing 30 min/day of sedentary time with 30 min/day of light-intensity physical activity at year 20 was associated with a lower composite risk score (-0.01 SD [95% CI, -0.02, -0.00]) at year 30, characterized by lower waist circumference (0.15 cm [95% CI, -0.27, 0.02]), insulin (0.20 μU/mL [95% CI, -0.35, -0.04]), and higher high-density lipoprotein cholesterol (0.20 mg/dL [95% CI, 0.00, 0.40]; all P<0.05). An increase of 30 min/day in MVPA from year 20 to year 30, when replacing an equivalent increase in sedentary time, was associated with a decrease in the composite risk score (-0.08 [95% CI, -0.13, -0.04]) over the same 10 years, characterized by a decrease in waist circumference (1.52 cm [95% CI, -2.21, -0.84]), insulin (-1.13 μU/mL [95% CI, -1.95, -0.31]), triglycerides (-6.92 mg/dL [95% CI, -11.69, -2.15]), and an increase in high-density lipoprotein cholesterol (1.59 mg/dL [95% CI, 0.45, 2.73]; all P<0.05). Conclusions Replacement of sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity is associated with improved cardiometabolic health 10 years later.

KW - Cardiometabolic risk

KW - Epidemiology

KW - Isotemporal substitution

KW - Physical activity

KW - Sedentary time

KW - Accelerometry/methods

KW - Blood Pressure/physiology

KW - Prospective Studies

KW - Cross-Sectional Studies

KW - Follow-Up Studies

KW - Humans

KW - Risk Factors

KW - Exercise/physiology

KW - Male

KW - Incidence

KW - Young Adult

KW - United States/epidemiology

KW - Time Factors

KW - Adolescent

KW - Adult

KW - Female

KW - Cardiovascular Diseases/diagnosis

KW - Sedentary Behavior

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DO - 10.1161/JAHA.118.010212

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JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

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ER -

Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors: The CARDIA study

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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