Associations between social, biologic, and behavioral factors and biomarkers of oxidative stress during pregnancy: Findings from four ECHO cohorts

Environmental influences on Child Health Outcomes

doi:10.1016/j.scitotenv.2022.155596

Associations between social, biologic, and behavioral factors and biomarkers of oxidative stress during pregnancy: Findings from four ECHO cohorts

Environmental influences on Child Health Outcomes

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background: Lower socioeconomic status (SES) and elevated psychosocial stress are known contributors to adverse pregnancy outcomes; however, biological mechanisms linking these factors to adverse pregnancy outcomes are not well-characterized. Oxidative stress may be an important, yet understudied mechanistic pathway. We used a pooled study design to examine biological, behavioral, and social factors as predictors of prenatal oxidative stress biomarkers. Methods: Leveraging four pregnancy cohorts from the Environmental influences on Child Health Outcomes (ECHO) Program spanning multiple geographic regions across the United States (U.S.) (N = 2082), we measured biomarkers of oxidative stress in urine samples at up to three time points during pregnancy, including 8-isoprostane-prostaglandin F_2α (8-isoPGF_2α), its major metabolite, 2,3-dinor-5,6-dihydro-15-F_2t-isoprostane, and prostaglandin F_2α (PGF_2α). Maternal age, pre-pregnancy body mass index, marital/partnered status, parity, and smoking status were included as biological and behavioral factors while race/ethnicity, maternal education, and stressful life events were considered social factors. We examined associations between each individual biological, behavioral, and social factor with oxidative stress biomarkers using multivariable-adjusted linear mixed models. Results: Numerous biological, behavioral, and social factors were associated with elevated levels of 8-isoPGF_2α, its major metabolite, and PGF_2α. Pregnant people who were current smokers relative to non-smokers or had less than a high school education relative to a college degree had 11.04% (95% confidence interval [CI] = −1.97%, 25.77%) and 9.13% (95% CI = -1.02%, 20.32%) higher levels of 8-isoPGF_2α, respectively. Conclusions: Oxidative stress biomarkers are elevated among pregnant people with higher socioeconomic disadvantage and may represent one pathway linking biological, behavioral, and social factors to adverse pregnancy and child health outcomes, which should be explored in future work.

Original language	English (US)
Article number	155596
Journal	Science of the Total Environment
Volume	835
DOIs	https://doi.org/10.1016/j.scitotenv.2022.155596
State	Published - Aug 20 2022

Bibliographical note

Funding Information:
Research reported in this publication was supported by the Environmental influences on Child Health Outcomes (ECHO) Program, Office of The Director, National Institutes of Health , under Award Numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (PRO Core), and UG3OD023251 , UH3OD023251 , UG3OD023272 , UH3OD023272 , UG3OD023271 , UH3OD023271 , UG3023305 , and UH3OD023305 . This work was additionally supported by the Children's Environmental Health and Disease Prevention Research Center ( ES022848 and RD83543401 ), T32 National Institutes of Health Institution Training Grant Predoctoral Traineeship in Endocrine, Developmental, and Reproductive Toxicology ( ES007326 ), United States Environmental Protection Agency ( RD83543301 ), National Institute of Environmental Health Sciences (NIEHS) ( P42ES017198 , P50ES026049 , P01ES022841 , R01ES02705 , R01ES025169 , R01ES016863 , P30ES019776 , P30ES030284 , and P30ES005022 ), and Intramural Research Program , NIEHS ( ZIAES103313 ). G.L.M. is supported by the Vanderbilt Diabetes Research Center with funding from the National Institute of Diabetes and Digestive and Kidney Diseases ( DK-20593 ).

Publisher Copyright:
© 2022 Elsevier B.V.

Keywords

Isoprostane
Oxidative stress
Pregnancy
Social determinants

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10.1016/j.scitotenv.2022.155596

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@article{d08e26161d8f43c0b10ab9d315d2b708,

title = "Associations between social, biologic, and behavioral factors and biomarkers of oxidative stress during pregnancy: Findings from four ECHO cohorts",

abstract = "Background: Lower socioeconomic status (SES) and elevated psychosocial stress are known contributors to adverse pregnancy outcomes; however, biological mechanisms linking these factors to adverse pregnancy outcomes are not well-characterized. Oxidative stress may be an important, yet understudied mechanistic pathway. We used a pooled study design to examine biological, behavioral, and social factors as predictors of prenatal oxidative stress biomarkers. Methods: Leveraging four pregnancy cohorts from the Environmental influences on Child Health Outcomes (ECHO) Program spanning multiple geographic regions across the United States (U.S.) (N = 2082), we measured biomarkers of oxidative stress in urine samples at up to three time points during pregnancy, including 8-isoprostane-prostaglandin F2α (8-isoPGF2α), its major metabolite, 2,3-dinor-5,6-dihydro-15-F2t-isoprostane, and prostaglandin F2α (PGF2α). Maternal age, pre-pregnancy body mass index, marital/partnered status, parity, and smoking status were included as biological and behavioral factors while race/ethnicity, maternal education, and stressful life events were considered social factors. We examined associations between each individual biological, behavioral, and social factor with oxidative stress biomarkers using multivariable-adjusted linear mixed models. Results: Numerous biological, behavioral, and social factors were associated with elevated levels of 8-isoPGF2α, its major metabolite, and PGF2α. Pregnant people who were current smokers relative to non-smokers or had less than a high school education relative to a college degree had 11.04% (95% confidence interval [CI] = −1.97%, 25.77%) and 9.13% (95% CI = -1.02%, 20.32%) higher levels of 8-isoPGF2α, respectively. Conclusions: Oxidative stress biomarkers are elevated among pregnant people with higher socioeconomic disadvantage and may represent one pathway linking biological, behavioral, and social factors to adverse pregnancy and child health outcomes, which should be explored in future work.",

keywords = "Isoprostane, Oxidative stress, Pregnancy, Social determinants",

author = "{Environmental influences on Child Health Outcomes} and Eick, {Stephanie M.} and Geiger, {Sarah Dee} and Akram Alshawabkeh and Max Aung and Emily Barrett and Bush, {Nicole R.} and Cordero, {Jos{\'e} F.} and Ferguson, {Kelly K.} and Meeker, {John D.} and Milne, {Ginger L.} and Nguyen, {Ruby H.N.} and Padula, {Amy M.} and Sheela Sathyanarayana and Welch, {Barrett M.} and Schantz, {Susan L.} and Woodruff, {Tracey J.} and Rachel Morello-Frosch",

note = "Funding Information: Research reported in this publication was supported by the Environmental influences on Child Health Outcomes (ECHO) Program, Office of The Director, National Institutes of Health , under Award Numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (PRO Core), and UG3OD023251 , UH3OD023251 , UG3OD023272 , UH3OD023272 , UG3OD023271 , UH3OD023271 , UG3023305 , and UH3OD023305 . This work was additionally supported by the Children's Environmental Health and Disease Prevention Research Center ( ES022848 and RD83543401 ), T32 National Institutes of Health Institution Training Grant Predoctoral Traineeship in Endocrine, Developmental, and Reproductive Toxicology ( ES007326 ), United States Environmental Protection Agency ( RD83543301 ), National Institute of Environmental Health Sciences (NIEHS) ( P42ES017198 , P50ES026049 , P01ES022841 , R01ES02705 , R01ES025169 , R01ES016863 , P30ES019776 , P30ES030284 , and P30ES005022 ), and Intramural Research Program , NIEHS ( ZIAES103313 ). G.L.M. is supported by the Vanderbilt Diabetes Research Center with funding from the National Institute of Diabetes and Digestive and Kidney Diseases ( DK-20593 ). Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = aug,

day = "20",

doi = "10.1016/j.scitotenv.2022.155596",

language = "English (US)",

volume = "835",

journal = "Science of the Total Environment",

issn = "0048-9697",

publisher = "Elsevier",

}

TY - JOUR

T1 - Associations between social, biologic, and behavioral factors and biomarkers of oxidative stress during pregnancy

T2 - Findings from four ECHO cohorts

AU - Environmental influences on Child Health Outcomes

AU - Eick, Stephanie M.

AU - Geiger, Sarah Dee

AU - Alshawabkeh, Akram

AU - Aung, Max

AU - Barrett, Emily

AU - Bush, Nicole R.

AU - Cordero, José F.

AU - Ferguson, Kelly K.

AU - Meeker, John D.

AU - Milne, Ginger L.

AU - Nguyen, Ruby H.N.

AU - Padula, Amy M.

AU - Sathyanarayana, Sheela

AU - Welch, Barrett M.

AU - Schantz, Susan L.

AU - Woodruff, Tracey J.

AU - Morello-Frosch, Rachel

N1 - Funding Information: Research reported in this publication was supported by the Environmental influences on Child Health Outcomes (ECHO) Program, Office of The Director, National Institutes of Health , under Award Numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (PRO Core), and UG3OD023251 , UH3OD023251 , UG3OD023272 , UH3OD023272 , UG3OD023271 , UH3OD023271 , UG3023305 , and UH3OD023305 . This work was additionally supported by the Children's Environmental Health and Disease Prevention Research Center ( ES022848 and RD83543401 ), T32 National Institutes of Health Institution Training Grant Predoctoral Traineeship in Endocrine, Developmental, and Reproductive Toxicology ( ES007326 ), United States Environmental Protection Agency ( RD83543301 ), National Institute of Environmental Health Sciences (NIEHS) ( P42ES017198 , P50ES026049 , P01ES022841 , R01ES02705 , R01ES025169 , R01ES016863 , P30ES019776 , P30ES030284 , and P30ES005022 ), and Intramural Research Program , NIEHS ( ZIAES103313 ). G.L.M. is supported by the Vanderbilt Diabetes Research Center with funding from the National Institute of Diabetes and Digestive and Kidney Diseases ( DK-20593 ). Publisher Copyright: © 2022 Elsevier B.V.

PY - 2022/8/20

Y1 - 2022/8/20

N2 - Background: Lower socioeconomic status (SES) and elevated psychosocial stress are known contributors to adverse pregnancy outcomes; however, biological mechanisms linking these factors to adverse pregnancy outcomes are not well-characterized. Oxidative stress may be an important, yet understudied mechanistic pathway. We used a pooled study design to examine biological, behavioral, and social factors as predictors of prenatal oxidative stress biomarkers. Methods: Leveraging four pregnancy cohorts from the Environmental influences on Child Health Outcomes (ECHO) Program spanning multiple geographic regions across the United States (U.S.) (N = 2082), we measured biomarkers of oxidative stress in urine samples at up to three time points during pregnancy, including 8-isoprostane-prostaglandin F2α (8-isoPGF2α), its major metabolite, 2,3-dinor-5,6-dihydro-15-F2t-isoprostane, and prostaglandin F2α (PGF2α). Maternal age, pre-pregnancy body mass index, marital/partnered status, parity, and smoking status were included as biological and behavioral factors while race/ethnicity, maternal education, and stressful life events were considered social factors. We examined associations between each individual biological, behavioral, and social factor with oxidative stress biomarkers using multivariable-adjusted linear mixed models. Results: Numerous biological, behavioral, and social factors were associated with elevated levels of 8-isoPGF2α, its major metabolite, and PGF2α. Pregnant people who were current smokers relative to non-smokers or had less than a high school education relative to a college degree had 11.04% (95% confidence interval [CI] = −1.97%, 25.77%) and 9.13% (95% CI = -1.02%, 20.32%) higher levels of 8-isoPGF2α, respectively. Conclusions: Oxidative stress biomarkers are elevated among pregnant people with higher socioeconomic disadvantage and may represent one pathway linking biological, behavioral, and social factors to adverse pregnancy and child health outcomes, which should be explored in future work.

AB - Background: Lower socioeconomic status (SES) and elevated psychosocial stress are known contributors to adverse pregnancy outcomes; however, biological mechanisms linking these factors to adverse pregnancy outcomes are not well-characterized. Oxidative stress may be an important, yet understudied mechanistic pathway. We used a pooled study design to examine biological, behavioral, and social factors as predictors of prenatal oxidative stress biomarkers. Methods: Leveraging four pregnancy cohorts from the Environmental influences on Child Health Outcomes (ECHO) Program spanning multiple geographic regions across the United States (U.S.) (N = 2082), we measured biomarkers of oxidative stress in urine samples at up to three time points during pregnancy, including 8-isoprostane-prostaglandin F2α (8-isoPGF2α), its major metabolite, 2,3-dinor-5,6-dihydro-15-F2t-isoprostane, and prostaglandin F2α (PGF2α). Maternal age, pre-pregnancy body mass index, marital/partnered status, parity, and smoking status were included as biological and behavioral factors while race/ethnicity, maternal education, and stressful life events were considered social factors. We examined associations between each individual biological, behavioral, and social factor with oxidative stress biomarkers using multivariable-adjusted linear mixed models. Results: Numerous biological, behavioral, and social factors were associated with elevated levels of 8-isoPGF2α, its major metabolite, and PGF2α. Pregnant people who were current smokers relative to non-smokers or had less than a high school education relative to a college degree had 11.04% (95% confidence interval [CI] = −1.97%, 25.77%) and 9.13% (95% CI = -1.02%, 20.32%) higher levels of 8-isoPGF2α, respectively. Conclusions: Oxidative stress biomarkers are elevated among pregnant people with higher socioeconomic disadvantage and may represent one pathway linking biological, behavioral, and social factors to adverse pregnancy and child health outcomes, which should be explored in future work.

KW - Isoprostane

KW - Oxidative stress

KW - Pregnancy

KW - Social determinants

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DO - 10.1016/j.scitotenv.2022.155596

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AN - SCOPUS:85129413158

SN - 0048-9697

VL - 835

JO - Science of the Total Environment

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ER -

Associations between social, biologic, and behavioral factors and biomarkers of oxidative stress during pregnancy: Findings from four ECHO cohorts

Abstract

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