Associations Between Nutrition, Gut Microbiome, and Health in A Novel Nonhuman Primate Model

Jonathan B. Clayton, Gabriel A. Al-Ghalith, Ha Thang Long, Bui Van Tuan, Francis Cabana, Hu Huang, Pajau Vangay, Tonya Ward, Vo Van Minh, Nguyen Ai Tam, Nguyen Tat Dat, Dominic A. Travis, Michael P. Murtaugh, Herbert Covert, Kenneth E. Glander, Tilo Nadler, Barbara Toddes, John C.M. Sha, Randy Singer, Dan KnightsTimothy J. Johnson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Red-shanked doucs (Pygathrix nemaeus) are endangered, foregut-fermenting colobine primates which are difficult to maintain in captivity. There are critical gaps in our understanding of their natural lifestyle, including dietary habits such as consumption of leaves, unripe fruit, flowers, seeds, and other plant parts. There is also a lack of understanding of enteric adaptations, including their unique microflora. To address these knowledge gaps, we used the douc as a model to study relationships between gastrointestinal microbial community structure and lifestyle. We analyzed published fecal samples as well as detailed dietary history from doucs with four distinct lifestyles (wild, semi-wild, semi-captive, and captive) and determined gastrointestinal bacterial microbiome composition using 16S rRNA sequencing. A clear gradient of microbiome composition was revealed along an axis of natural lifestyle disruption, including significant associations with diet, biodiversity, and microbial function. We also identified potential microbial biomarkers of douc dysbiosis, including Bacteroides and Prevotella, which may be related to health. Our results suggest a gradient-like shift in captivity causes an attendant shift to severe gut dysbiosis, thereby resulting in gastrointestinal issues.

Original languageEnglish (US)
Article number11159
JournalScientific reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Primates
Life Style
Dysbiosis
Health
Prevotella
Cercopithecidae
Bacteroides
Microbiota
Biodiversity
Feeding Behavior
Fruit
Seeds
Biomarkers
Diet
Gastrointestinal Microbiome

Cite this

Associations Between Nutrition, Gut Microbiome, and Health in A Novel Nonhuman Primate Model. / Clayton, Jonathan B.; Al-Ghalith, Gabriel A.; Long, Ha Thang; Tuan, Bui Van; Cabana, Francis; Huang, Hu; Vangay, Pajau; Ward, Tonya; Minh, Vo Van; Tam, Nguyen Ai; Dat, Nguyen Tat; Travis, Dominic A.; Murtaugh, Michael P.; Covert, Herbert; Glander, Kenneth E.; Nadler, Tilo; Toddes, Barbara; Sha, John C.M.; Singer, Randy; Knights, Dan; Johnson, Timothy J.

In: Scientific reports, Vol. 8, No. 1, 11159, 01.12.2018.

Research output: Contribution to journalArticle

Clayton, JB, Al-Ghalith, GA, Long, HT, Tuan, BV, Cabana, F, Huang, H, Vangay, P, Ward, T, Minh, VV, Tam, NA, Dat, NT, Travis, DA, Murtaugh, MP, Covert, H, Glander, KE, Nadler, T, Toddes, B, Sha, JCM, Singer, R, Knights, D & Johnson, TJ 2018, 'Associations Between Nutrition, Gut Microbiome, and Health in A Novel Nonhuman Primate Model', Scientific reports, vol. 8, no. 1, 11159. https://doi.org/10.1038/s41598-018-29277-x
Clayton, Jonathan B. ; Al-Ghalith, Gabriel A. ; Long, Ha Thang ; Tuan, Bui Van ; Cabana, Francis ; Huang, Hu ; Vangay, Pajau ; Ward, Tonya ; Minh, Vo Van ; Tam, Nguyen Ai ; Dat, Nguyen Tat ; Travis, Dominic A. ; Murtaugh, Michael P. ; Covert, Herbert ; Glander, Kenneth E. ; Nadler, Tilo ; Toddes, Barbara ; Sha, John C.M. ; Singer, Randy ; Knights, Dan ; Johnson, Timothy J. / Associations Between Nutrition, Gut Microbiome, and Health in A Novel Nonhuman Primate Model. In: Scientific reports. 2018 ; Vol. 8, No. 1.
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