TY - JOUR
T1 - Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women's Health Study
AU - Razzak, Anthony A.
AU - Oxentenko, Amy S.
AU - Vierkant, Robert A.
AU - Tillmans, Lori S.
AU - Wang, Alice H.
AU - Weisenberger, Daniel J.
AU - Laird, Peter W.
AU - Lynch, Charles F.
AU - Anderson, Kristin E.
AU - French, Amy J.
AU - Haile, Robert W.
AU - Harnack, Lisa J.
AU - Potter, John D.
AU - Slager, Susan L.
AU - Smyrk, Thomas C.
AU - Thibodeau, Stephen N.
AU - Cerhan, James R.
AU - Limburg, Paul J.
N1 - Funding Information:
This study was funded in part by National Cancer Institute grants R01 CA39742 and R01 CA107333.
PY - 2012/10/1
Y1 - 2012/10/1
N2 - Folate and related micronturients may affect colorectal cancer (CRC) risk, but the molecular mechanism(s) remain incompletely defined. We analyzed associations between dietary folate, vitamin B6, vitamin B12, and methionine with incident CRC, overall and by microsatellite instability (MSS/MSI-L or MSI-H), CpG island methylator phenotype (CIMP-negative or CIMP-positive), BRAF mutation (negative or positive), and KRAS mutation (negative or positive) status in the prospective, population-based Iowa Women's Health Study (IWHS; 55-69years at baseline; n = 41,836). Intake estimates were obtained from baseline, self-reported food frequency questionnaires. Molecular marker data were obtained for 514 incident CRC cases. Folate intake was inversely associated with overall CRC risk in age-adjusted Cox regression models, whereas methionine intake was inversely associated with overall CRC risk in multivariable-adjusted models [relative risk (RR) = 0.81; 95% CI = 0.69-0.95; P trend = 0.001 and RR = 0.72; 95% CI = 0.54-0.96; P trend = 0.03 for highest vs. lowest quartiles, respectively]. None of the dietary exposures were associated with MSI, CIMP, BRAF, or KRAS defined CRC subtypes. These data provide minimal support for major effects from the examined micronutrients on overall or molecularly defined CRC risks in the IWHS cohort.
AB - Folate and related micronturients may affect colorectal cancer (CRC) risk, but the molecular mechanism(s) remain incompletely defined. We analyzed associations between dietary folate, vitamin B6, vitamin B12, and methionine with incident CRC, overall and by microsatellite instability (MSS/MSI-L or MSI-H), CpG island methylator phenotype (CIMP-negative or CIMP-positive), BRAF mutation (negative or positive), and KRAS mutation (negative or positive) status in the prospective, population-based Iowa Women's Health Study (IWHS; 55-69years at baseline; n = 41,836). Intake estimates were obtained from baseline, self-reported food frequency questionnaires. Molecular marker data were obtained for 514 incident CRC cases. Folate intake was inversely associated with overall CRC risk in age-adjusted Cox regression models, whereas methionine intake was inversely associated with overall CRC risk in multivariable-adjusted models [relative risk (RR) = 0.81; 95% CI = 0.69-0.95; P trend = 0.001 and RR = 0.72; 95% CI = 0.54-0.96; P trend = 0.03 for highest vs. lowest quartiles, respectively]. None of the dietary exposures were associated with MSI, CIMP, BRAF, or KRAS defined CRC subtypes. These data provide minimal support for major effects from the examined micronutrients on overall or molecularly defined CRC risks in the IWHS cohort.
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U2 - 10.1080/01635581.2012.714833
DO - 10.1080/01635581.2012.714833
M3 - Article
C2 - 23061900
AN - SCOPUS:84867796571
SN - 0163-5581
VL - 64
SP - 899
EP - 910
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 7
ER -