Associations between intake of calcium, magnesium and phosphorus and risk of pancreatic cancer: A population-based, case-control study in Minnesota

Hao Fan, Yunpeng Yu, Haocheng Nan, Margaret Hoyt, Michael K. Reger, Anna Prizment, Kristin E. Anderson, Jianjun Zhang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Experimental studies suggest that abnormal levels of Ca, Mg and phosphorus are implicated in pancreatic carcinogenesis. We investigated the associations between intakes of these minerals and the risk of pancreatic cancer in a case-control study conducted in 1994-1998. Cases of pancreatic cancer (n 150) were recruited from all hospitals in the metropolitan area of the Twin Cities and Mayo Clinic, Minnesota. Controls (n 459) were randomly selected from the general population and frequency matched to cases by age, sex and race. All dietary variables were adjusted for energy intake using the residual method prior to data analysis. Logistic regression was performed to evaluate the associations between intake of three nutrients examined and the risk of pancreatic cancer. Total intake of Ca (936 v. 1026 mg/d) and dietary intake of Mg (315 v. 331 mg/d) and phosphorus (1350 v. 1402 mg/d) were significantly lower in cases than in controls. After adjustment for confounders, there were not significant associations of total and dietary intakes of Ca, Mg and phosphorus with the risk of pancreatic cancer. In addition, no significant interactions exist between intakes of these minerals and total fat on pancreatic cancer risk. In conclusion, the present study does not suggest that intakes of Ca, Mg and phosphorus were significantly associated with the risk of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)1549-1557
Number of pages9
JournalBritish Journal of Nutrition
Volume126
Issue number10
Early online dateJan 26 2021
DOIs
StatePublished - Nov 28 2021

Bibliographical note

Funding Information:
Research reported in this publication was supported by the National Institutes of Health (K.E.A., grant number R01CA58697). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The National Institutes of Health had no role in the design, analysis or writing of this article.

Publisher Copyright:
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Keywords

  • Case-control study
  • Key words: Calcium
  • Magnesium
  • Pancreatic cancer
  • Phosphorus

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

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