Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study

Elizabeth C. Oelsner, Benjamin M. Smith, Eric A. Hoffman, Aaron R. Folsom, Steven M. Kawut, Joel D. Kaufman, Ani Manichaikul, David J. Lederer, Joseph E. Schwartz, Karol E. Watson, Paul L. Enright, John H.M. Austin, Joao A.C. Lima, Steven J. Shea, Robert G. Barr

Research output: Contribution to journalLetterpeer-review

5 Scopus citations

Abstract

Emphysema on CT is associated with accelerated lung function decline in heavy smokers and patients with COPD; however, in the general population, it is not known whether greater emphysema-like lung on CT is associated with incident COPD. We used data from 2045 adult participants without initial prebronchodilator airflow limitation, classified by FEV1/FVC<0.70, in the Multi-Ethnic Study of Atherosclerosis. Emphysema-like lung on baseline cardiac CT, defined as per cent low attenuation areas<-950HU>upper limit of normal, was associated with increased odds of incident airflow limitation at 5-year follow-up on both prebronchodilator (adjusted OR 2.62, 95% CI 1.47 to 4.67) and postbronchodilator (adjusted OR 4.38, 95% CI 1.63 to 11.74) spirometry, independent of smoking history. These results support investigation into whether emphysema-like lung could be informative for COPD risk stratification.

Original languageEnglish (US)
Pages (from-to)486-488
Number of pages3
JournalThorax
Volume73
Issue number5
DOIs
StatePublished - May 1 2018

Keywords

  • COPD epidemiology
  • emphysema
  • imaging/CT MRI

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