Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study

Elizabeth C. Oelsner; Benjamin M. Smith; Eric A. Hoffman; Aaron R. Folsom; Steven M. Kawut; Joel D. Kaufman; Ani Manichaikul; David J. Lederer; Joseph E. Schwartz; Karol E. Watson; Paul L. Enright; John H.M. Austin; Joao A.C. Lima; Steven J. Shea; Robert G. Barr

doi:10.1136/thoraxjnl-2017-210842

Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study

Elizabeth C. Oelsner, Benjamin M. Smith, Eric A. Hoffman, Aaron R. Folsom, Steven M. Kawut, Joel D. Kaufman, Ani Manichaikul, David J. Lederer, Joseph E. Schwartz, Karol E. Watson, Paul L. Enright, John H.M. Austin, Joao A.C. Lima, Steven J. Shea, Robert G. Barr

Epidemiology & Community Health

Research output: Contribution to journal › Letter › peer-review

11 Scopus citations

Abstract

Emphysema on CT is associated with accelerated lung function decline in heavy smokers and patients with COPD; however, in the general population, it is not known whether greater emphysema-like lung on CT is associated with incident COPD. We used data from 2045 adult participants without initial prebronchodilator airflow limitation, classified by FEV1/FVC<0.70, in the Multi-Ethnic Study of Atherosclerosis. Emphysema-like lung on baseline cardiac CT, defined as per cent low attenuation areas<-950HU>upper limit of normal, was associated with increased odds of incident airflow limitation at 5-year follow-up on both prebronchodilator (adjusted OR 2.62, 95% CI 1.47 to 4.67) and postbronchodilator (adjusted OR 4.38, 95% CI 1.63 to 11.74) spirometry, independent of smoking history. These results support investigation into whether emphysema-like lung could be informative for COPD risk stratification.

Original language	English (US)
Pages (from-to)	486-488
Number of pages	3
Journal	Thorax
Volume	73
Issue number	5
DOIs	https://doi.org/10.1136/thoraxjnl-2017-210842
State	Published - May 1 2018

Bibliographical note

Publisher Copyright:
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Keywords

COPD epidemiology
emphysema
imaging/CT MRI

Publisher link

10.1136/thoraxjnl-2017-210842

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903958

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Oelsner, E. C., Smith, B. M., Hoffman, E. A., Folsom, A. R., Kawut, S. M., Kaufman, J. D., Manichaikul, A., Lederer, D. J., Schwartz, J. E., Watson, K. E., Enright, P. L., Austin, J. H. M., Lima, J. A. C., Shea, S. J., & Barr, R. G. (2018). Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study. Thorax, 73(5), 486-488. https://doi.org/10.1136/thoraxjnl-2017-210842

Oelsner, EC, Smith, BM, Hoffman, EA, Folsom, AR, Kawut, SM, Kaufman, JD, Manichaikul, A, Lederer, DJ, Schwartz, JE, Watson, KE, Enright, PL, Austin, JHM, Lima, JAC, Shea, SJ & Barr, RG 2018, 'Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study', Thorax, vol. 73, no. 5, pp. 486-488. https://doi.org/10.1136/thoraxjnl-2017-210842

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abstract = "Emphysema on CT is associated with accelerated lung function decline in heavy smokers and patients with COPD; however, in the general population, it is not known whether greater emphysema-like lung on CT is associated with incident COPD. We used data from 2045 adult participants without initial prebronchodilator airflow limitation, classified by FEV1/FVC<0.70, in the Multi-Ethnic Study of Atherosclerosis. Emphysema-like lung on baseline cardiac CT, defined as per cent low attenuation areas<-950HU>upper limit of normal, was associated with increased odds of incident airflow limitation at 5-year follow-up on both prebronchodilator (adjusted OR 2.62, 95% CI 1.47 to 4.67) and postbronchodilator (adjusted OR 4.38, 95% CI 1.63 to 11.74) spirometry, independent of smoking history. These results support investigation into whether emphysema-like lung could be informative for COPD risk stratification.",

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AU - Folsom, Aaron R.

AU - Kawut, Steven M.

AU - Kaufman, Joel D.

AU - Manichaikul, Ani

AU - Lederer, David J.

AU - Schwartz, Joseph E.

AU - Watson, Karol E.

AU - Enright, Paul L.

AU - Austin, John H.M.

AU - Lima, Joao A.C.

AU - Shea, Steven J.

AU - Barr, Robert G.

N1 - Publisher Copyright: © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Emphysema on CT is associated with accelerated lung function decline in heavy smokers and patients with COPD; however, in the general population, it is not known whether greater emphysema-like lung on CT is associated with incident COPD. We used data from 2045 adult participants without initial prebronchodilator airflow limitation, classified by FEV1/FVC<0.70, in the Multi-Ethnic Study of Atherosclerosis. Emphysema-like lung on baseline cardiac CT, defined as per cent low attenuation areas<-950HU>upper limit of normal, was associated with increased odds of incident airflow limitation at 5-year follow-up on both prebronchodilator (adjusted OR 2.62, 95% CI 1.47 to 4.67) and postbronchodilator (adjusted OR 4.38, 95% CI 1.63 to 11.74) spirometry, independent of smoking history. These results support investigation into whether emphysema-like lung could be informative for COPD risk stratification.

AB - Emphysema on CT is associated with accelerated lung function decline in heavy smokers and patients with COPD; however, in the general population, it is not known whether greater emphysema-like lung on CT is associated with incident COPD. We used data from 2045 adult participants without initial prebronchodilator airflow limitation, classified by FEV1/FVC<0.70, in the Multi-Ethnic Study of Atherosclerosis. Emphysema-like lung on baseline cardiac CT, defined as per cent low attenuation areas<-950HU>upper limit of normal, was associated with increased odds of incident airflow limitation at 5-year follow-up on both prebronchodilator (adjusted OR 2.62, 95% CI 1.47 to 4.67) and postbronchodilator (adjusted OR 4.38, 95% CI 1.63 to 11.74) spirometry, independent of smoking history. These results support investigation into whether emphysema-like lung could be informative for COPD risk stratification.

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KW - imaging/CT MRI

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Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study

Abstract

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